PD53-04 DOUBLE-BLIND PROSPECTIVE RANDOMIZED CLINICAL TRIAL COMPARING REGULAR AND MOSES MODES OF HOLMIUM LASER LITHOTRIPSY: PRELIMINARY RESULTS

Abstract

You have accessJournal of UrologyStone Disease: Surgical Therapy V1 Apr 2018PD53-04 DOUBLE-BLIND PROSPECTIVE RANDOMIZED CLINICAL TRIAL COMPARING REGULAR AND MOSES MODES OF HOLMIUM LASER LITHOTRIPSY: PRELIMINARY RESULTS Ahmed Ibrahim, Nader Fahmy, Serge Carrier, Mostafa Elhilali, and Sero Andonian Ahmed IbrahimAhmed Ibrahim More articles by this author , Nader FahmyNader Fahmy More articles by this author , Serge CarrierSerge Carrier More articles by this author , Mostafa ElhilaliMostafa Elhilali More articles by this author , and Sero AndonianSero Andonian More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.2500AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Moses Technology has been shown to improve the fragmentation efficiency and reduced stone retropulsion both in in vivo and in vitro studies. However, there are no randomized trials evaluating effectiveness of this new technology during laser lithotripsy. Therefore, the objective was to compare Regular and Moses modes of holmium laser lithotripsy in terms of stone fragmentation efficiency and perioperative complications. METHODS After obtaining ethics approval, a prospective double-blind randomized trial was conducted for patients undergoing holmium laser lithotripsy. Patients were randomly assigned to have holmium laser lithotripsy with either Regular or Moses modes. Both patients and surgeons were blinded to the laser mode. All procedures were performed by four experienced urologists. Lumenis 120W generator with 200 Moses D/F/L fibers were used for all cases. Demographic data, stone parameters, peri-operative complications and success rates were compared. The degree of stone retropulsion was graded on a Likert scale from zero (no retropulsion) to 3 (maximum retropulsion). RESULTS A total of 66 patients were included in the study (33 per each arm). Both groups were comparable in terms of age, and pre-operative stone size (1.7 vs. 1.6 cm, p>0.05). When compared with the Regular mode, Moses Technology was associated with significantly lower fragmentation time (23.4 vs. 17.5 min, p<0.05) and total procedural time (53 vs. 42.1 min, p<0.05). However, there were no significant differences in terms of lasing time (6.5 vs. 7.1 min, p>0.05) and total energy applied to the stones (10.8 vs. 11.5 KJ, p>0.05). When compared between Regular and Moses modes, Moses technology was associated with significantly less retropulsion (mean grade was 1 vs. 0.4, p<0.05). There was no significant difference between both modes in terms of intra-operative complications (12.1 % vs. 3%, p>0.05). Only one case from Moses group had a small ureteral perforation requiring prolonged indwelling ureteral stenting. The success rate at the end of 1 month was comparable between both groups (90.1 vs. 87.9 %, p> 0.05). CONCLUSIONS Moses technology is associated with significantly lower fragmentation and procedural times. The reduced fragmentation time could be explained by the significantly lower reropulsion of the stones during laser lithotripsy; thus improving stone fragmentation efficiency. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e1047 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Ahmed Ibrahim More articles by this author Nader Fahmy More articles by this author Serge Carrier More articles by this author Mostafa Elhilali More articles by this author Sero Andonian More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...