PD50-05 IS THERE A PROTECTIVE ROLE OF TESTOSTERONE AGAINST HIGH-GRADE PROSTATE CANCER? INCIDENCE AND SEVERITY OF PROSTATE CANCER IN 553 PATIENTS UNDERGOING PROSTATE BIOPSY IN A PROSPECTIVE DATA REGISTER

Abstract

You have accessJournal of UrologySexual Function/Dysfunction: Medical, Hormonal & Non-surgical Therapy II1 Apr 2016PD50-05 IS THERE A PROTECTIVE ROLE OF TESTOSTERONE AGAINST HIGH-GRADE PROSTATE CANCER? INCIDENCE AND SEVERITY OF PROSTATE CANCER IN 553 PATIENTS UNDERGOING PROSTATE BIOPSY IN A PROSPECTIVE DATA REGISTER Aksam Yassin, Mahmoud Salman, and Yousef Almehmadi Aksam YassinAksam Yassin More articles by this author , Mahmoud SalmanMahmoud Salman More articles by this author , and Yousef AlmehmadiYousef Almehmadi More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2795AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Major concern regarding testosterone therapy (TRT) in middle-aged and elderly men is still prostate safety or cancer. METHODS 553 prostate biopsies (2008-2013) were performed at our institute. 22 patients refused biopsy. We investigated incidence and severity of PCa in three groups: hypogonadal (T≤350 ng/dl) men receiving TRT, hypogonadal untreated, and eugonadal men. All groups underwent similar screening intensity of at least once per year. Biopsies were performed when indicated according to EAU guidelines. RESULTS In 42 hypogonadal men receiving TRT, 7 (16.7%) had a positive biopsy. Of these, 5 had a Gleason score ≤6 (71.4%) and 2 subjects a Gleason score >6 (28.6%). Predominant Gleason score was 3 in all 7 men (100%). Tumor grade was II in 6 (85.7%) and II-III in 1 (14.3%) men. 162 untreated hypogonadal men, 84 (51.9%) had a positive biopsy. Of these, 34 had a Gleason score ≤6 (40.5%) and 50 a Gleason score >6 (59.5%). Predominant Gleason score was 3 in 65 (77.4%), 4 in 17 (20.2%) and 5 in 2 (2.4%) men. Tumor grade was II in 35 (41.7%), II-III in 10 (11.9%), III in 34 (40.5%) and IV in 5 (6.0%) men. In 349 eugonadal men, 132 (37.8%) had a positive biopsy. Of these, 56 had a Gleason score ≤6 (42.4%) and 76 a Gleason score >6 (57.6%). Predominant Gleason score was 3 in 109 (82.6%), 4 in 22 (16.7%) and 5 in 1 (0.1%) men. Tumor grade was II in 59 (44.7%), II-III in 6 (4.5%), III in 63 (47.7%) and IV in 4 (3.0%) men. CONCLUSIONS The incidence of positive prostate biopsies was lowest in hypogonadal men receiving TRT. The severity of PCa in terms of Staging and Grading was significantly lower in hypogonadal patients receiving TRT. TRT may protect against high-grade PCa. Protective role of TRT against PCa must be confirmed in larger studies. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e1187 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Aksam Yassin More articles by this author Mahmoud Salman More articles by this author Yousef Almehmadi More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...