PD49-04 ONCOLOGICAL OUTCOMES AND PATTERNS OF RECURRENCE OF PENILE SPARING APPROACHES FOR CARCINOMA OF THE PENIS: A RETROSPECTIVE, MULTICENTER COHORT ANALYSIS

Abstract

You have accessJournal of UrologySexual Function/Dysfunction: Penis/Testis/Urethra: Benign Disease & Malignant Disease I1 Apr 2017PD49-04 ONCOLOGICAL OUTCOMES AND PATTERNS OF RECURRENCE OF PENILE SPARING APPROACHES FOR CARCINOMA OF THE PENIS: A RETROSPECTIVE, MULTICENTER COHORT ANALYSIS Juan Chipollini, Adam Baumgarten, Dominic Tang, Sylvia Yan, Sarah Ottenhof, Yao Zhu, Ding-wei Ye, Chris Protzel, Simon Horenblas, Nicholas Watkin, and Philippe Spiess Juan ChipolliniJuan Chipollini More articles by this author , Adam BaumgartenAdam Baumgarten More articles by this author , Dominic TangDominic Tang More articles by this author , Sylvia YanSylvia Yan More articles by this author , Sarah OttenhofSarah Ottenhof More articles by this author , Yao ZhuYao Zhu More articles by this author , Ding-wei YeDing-wei Ye More articles by this author , Chris ProtzelChris Protzel More articles by this author , Simon HorenblasSimon Horenblas More articles by this author , Nicholas WatkinNicholas Watkin More articles by this author , and Philippe SpiessPhilippe Spiess More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.2228AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Use of penile sparing surgery (PSS) for penile carcinoma (PC) has been well characterized for low stages of the disease. In this present study we analyzed the outcomes of patients treated with circumcision, partial/total glansectomy, laser ablation, or wide local excision (WLE) for primary PC. METHODS We included 1260 consecutive patients who underwent PSS at 5 academic institutions from July 2000 to June 2015. Tumor and patient characteristics such as age, tumor size (cm), tumor grade and pathological stage were recorded and analyzed. Kaplan-Meier analysis was performed to evaluate 1 year, 2 year and 5 year recurrence free survival (RFS) among the groups. Multivariable Cox proportional hazards regression was used to assess prognostic factors for RFS and overall survival (OS). RESULTS Glansectomy patients had higher size, grade and pathologic stage tumors at time of surgery (p < 0.05). At a median follow up of 39.9 months, 37.1 % of patients treated with laser ablation had a local recurrence vs. those who underwent glansectomy or WLE alone (7.6 and 19.5%, respectively; p < 0.001). Patients who had laser procedures also had worse 1-yr, 2-yr and 5-yr RFS (74.4, 65.1 and 51%) vs. glansectomy (81.2, 72.4 and 68.8%, respectively) or WLE (80.3, 66.7 and 55.4%, respectively) (p = 0.056). Mutlivariable analysis found tumor grade (HR = 1.5, p <0.001) and corporal invasion (HR = 1.4, p = 0.05) to be significant, independent predictors for disease recurrence. Age was a significant prognosticator for OS (HR = 1.1, p < 0.001). CONCLUSIONS Tumor grade and corporal invasion were found as independent predictors of disease recurrence after penile sparing treatments. Patients treated with laser ablative techniques had worse recurrence outcomes. Strict surveillance guidelines for these patients are greatly needed. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e975 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Juan Chipollini More articles by this author Adam Baumgarten More articles by this author Dominic Tang More articles by this author Sylvia Yan More articles by this author Sarah Ottenhof More articles by this author Yao Zhu More articles by this author Ding-wei Ye More articles by this author Chris Protzel More articles by this author Simon Horenblas More articles by this author Nicholas Watkin More articles by this author Philippe Spiess More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...