PD48-04 THE ASSOCIATION BETWEEN NADIR PROSTATE SPECIFIC ANTIGEN VALUE AND BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY

Abstract

You have accessJournal of UrologyProstate Cancer: Detection & Screening V (PD48)1 Apr 2020PD48-04 THE ASSOCIATION BETWEEN NADIR PROSTATE SPECIFIC ANTIGEN VALUE AND BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY Jae Hoon Chung*, Seong Soo Jeon, Jae Yong Jeong, Minyong Kang, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, and Hyun Moo Lee Jae Hoon Chung*Jae Hoon Chung* More articles by this author , Seong Soo JeonSeong Soo Jeon More articles by this author , Jae Yong JeongJae Yong Jeong More articles by this author , Minyong KangMinyong Kang More articles by this author , Hyun Hwan SungHyun Hwan Sung More articles by this author , Hwang Gyun JeonHwang Gyun Jeon More articles by this author , Byong Chang JeongByong Chang Jeong More articles by this author , Seong Il SeoSeong Il Seo More articles by this author , and Hyun Moo LeeHyun Moo Lee More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000942.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The hypersensitive prostate specific antigen (PSA) test can measured in 0.01 ng/mL units, and its efficacy for screening after radical prostatectomy (RP) has been reported. In this study, we assessed the patients who underwent RP to evaluate whether the nadir value affects biochemical recurrence (BCR). METHODS: From 1995 to 2012, the patients who had N0, negative resection margin and nadir PSA of less than 0.2 ng/mL were evaluated. The characteristics, pathological outcomes, PSA after RP and BCR were assessed. RESULTS: A total of 1483 patients were enrolled. Among them, 323 (21.78%) patients showed BCR after RP. The mean age of BCR group was 63.86±7.31 years and in no-recurrence group was 64.06±6.82 years (p=0.645) The mean preoperative PSA of the BCR group was 9.75 ± 6.92 ng/mL and the no-recurrence group was 6.71 ± 5.19 ng/mL (p<0.001). The mean time to nadir in BCR group was 4.64±7.65 months and 7.43±12.46 months in no-recurrence group (p<0.001). In BCR group, mean PSA nadir value was 0.035±0.034 ng/mL and mean nadir value in no-recurrence group was 0.014±0.009 ng/mL (p<0.001) (Table 1). In multivariable Cox regression analyses, gleason score, positive biopsy core percentages, American Society of Anesthesiologists score 5, minimal invasive surgery, nadir PSA value and time to nadir after surgery was associated BCR, independently (Table 2). The mean BCR occurred at 48.23 ± 2.01 months after RP, and there was a significant difference in BCR occurrence according to nadir PSA value (p <0.001) (Figure 1). CONCLUSIONS: PSA nadir value predicts the risk of BCR after RP. Higher nadir value may identify candidates for adjuvant or salvage therapies. Source of Funding: none © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e994-e995 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jae Hoon Chung* More articles by this author Seong Soo Jeon More articles by this author Jae Yong Jeong More articles by this author Minyong Kang More articles by this author Hyun Hwan Sung More articles by this author Hwang Gyun Jeon More articles by this author Byong Chang Jeong More articles by this author Seong Il Seo More articles by this author Hyun Moo Lee More articles by this author Expand All Advertisement PDF downloadLoading ...