PD42-07 RADICAL VS PARTIAL CYSTECTOMY FOR URACHAL CARCINOMA: A POPULATION-BASED ANALYSIS

Abstract

You have accessJournal of UrologyCME1 May 2022PD42-07 RADICAL VS PARTIAL CYSTECTOMY FOR URACHAL CARCINOMA: A POPULATION-BASED ANALYSIS Rocco Simone Flammia, Francesco Chierigo, Benedikt Hoeh, Gabriele Sorce, Christoph Würnschimmel, Zhe Tian, Costantino Leonardo, Derya Tilki, Felix Chun, Carlo Terrone, Francesco Montorsi, Shahrokh Shariat, Michele Gallucci, and Pierre Karakiewicz Rocco Simone FlammiaRocco Simone Flammia More articles by this author , Francesco ChierigoFrancesco Chierigo More articles by this author , Benedikt HoehBenedikt Hoeh More articles by this author , Gabriele SorceGabriele Sorce More articles by this author , Christoph WürnschimmelChristoph Würnschimmel More articles by this author , Zhe TianZhe Tian More articles by this author , Costantino LeonardoCostantino Leonardo More articles by this author , Derya TilkiDerya Tilki More articles by this author , Felix ChunFelix Chun More articles by this author , Carlo TerroneCarlo Terrone More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , Shahrokh ShariatShahrokh Shariat More articles by this author , Michele GallucciMichele Gallucci More articles by this author , and Pierre Karakiewicz Pierre Karakiewicz More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002603.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Partial cystectomy (PC) represents the standard of care for non-metastatic urachal carcinoma (UrC). We tested whether radical cystectomy (RC) may hold a greater survival benefit. METHODS: Within the SEER database (2004-2016), we identified non-metastatic UrC patients aged ≥ 18 years. Estimated annual percentage change (EAPC) was applied to examine RC rate, as well as stage distribution over time. Kaplan-Meier plots and Cox regression models addressed cancer-specific mortality (CSM). All CSM analyses were repeated after inverse probability of treatment weighting (IPTW) to control for differences between RC vs PC patients. RESULTS: We identified 392 non-metastatic UrC patients treated with cystectomy. Of those, 55 (14%) underwent RC vs 337 (86%) underwent PC. RC patients harbored higher stage (non-organ confined, 58 vs 29%, p=0.03) higher grade (GG3-GG4, 56 vs 29%, p<0.001) and exhibited higher rate of PLND (84 vs 55%, p<0.001) than their PC counterparts. RC rates were higher in non-organ confined (NOC) vs organ-confined (OC) patients (17 vs 10%, p=0.04). RC rates decreased over time from 2004 to 2016 (-6%, p=0.007). Five-year CSM-free survival rates were respectively 60 vs 71% for RC vs PC (multivariable HR of 1.37 p=0.2). After IPTW, five-year CSM-free survival rates were respectively 69 vs 70% for RC vs PC (IPTW-HR of 1.05, p=0.9). CONCLUSIONS: RC rate is low in non-metastatic UrC and decreased over time. RC use instead of PC use does not result in lower CSM. In consequence, PC use should continue, unless contraindicated due to either extension of primary tumor or insufficient bladder capacity. Source of Funding: none © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e697 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Rocco Simone Flammia More articles by this author Francesco Chierigo More articles by this author Benedikt Hoeh More articles by this author Gabriele Sorce More articles by this author Christoph Würnschimmel More articles by this author Zhe Tian More articles by this author Costantino Leonardo More articles by this author Derya Tilki More articles by this author Felix Chun More articles by this author Carlo Terrone More articles by this author Francesco Montorsi More articles by this author Shahrokh Shariat More articles by this author Michele Gallucci More articles by this author Pierre Karakiewicz More articles by this author Expand All Advertisement PDF DownloadLoading ...