PD39-05 WORSENED URINARY STORAGE SYMPTOMS AND DECREASED QUALITY OF LIFE PREDICTS LOW TESTOSTERONE IN A CARDIOLOGY CLINIC POPULATION

Abstract

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Epidemiology and Natural History1 Apr 2015PD39-05 WORSENED URINARY STORAGE SYMPTOMS AND DECREASED QUALITY OF LIFE PREDICTS LOW TESTOSTERONE IN A CARDIOLOGY CLINIC POPULATION Michael Kottwitz, Joel F. Koenig, Bradford Stevenson, Randy Sulaver, Georgia Mueller, and Tobias S. Kohler Michael KottwitzMichael Kottwitz More articles by this author , Joel F. KoenigJoel F. Koenig More articles by this author , Bradford StevensonBradford Stevenson More articles by this author , Randy SulaverRandy Sulaver More articles by this author , Georgia MuellerGeorgia Mueller More articles by this author , and Tobias S. KohlerTobias S. Kohler More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2400AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Previous data from the CUPPID trial have demonstrated the increased prevalence of low testosterone (T) in male cardiology patients. Here we sought to assess relationships between low T and lower urinary tract symptoms (LUTS). METHODS We assessed a cohort of 200 consecutive men within a cardiology clinic via IIEF−15, IPSS, ADAM, and previous ED treatment questionnaires, serum total testosterone (T), estradiol (E), and sex hormone binding globulin (SHBG). Data were collected on patient age, BMI, cardiac history and comorbidities. We performed Spearman correlations to explore the association between CFT & urinary complaints and quality of life from the IPSS. Next, we performed a regression model to predict storage symptoms with low CFT adjusting for diabetes, diuretic use, stroke, age, BMI, smoking, and IIEF6 total score. RESULTS 200 patients were included in the study (mean age 67). Mean CFT and T:E were 5.4ng/dl and 8.2 respectively. Prevalence of low CFT was 79% while low total T was only 55%. Prevalence of moderate to severe LUTS was 62%. Decreasing CFT predicted worse LUTS (p = 0.02). Nocturia (p=0.0008), urgency (p=0.0186), intermittency (p=0.007) and quality of life score (p=0.0183) each were significantly inversely related to low CFT with correlation coefficients of -0.24, -0.17, -0.19, and -0.17 respectively. There was an association between low CFT and frequency, which neared significance (p=0.062, r=-0.24). Using stepwise selection worse storage symptom scores (but not obstructive symptom scores) predicted low CFT after adjusting for covariates (p=.0015, R2 =.15). Our model showed a 4 point worsening in storage symptoms resulted in a 0.88 ng/dl decrease in CFT and retained only age (p = < 0.001), BMI (p = 0.0007) and storage symptoms (p = 0.0015) as statistically significant variables. CONCLUSIONS In our cohort, worsened storage symptoms including nocturia, urgency, intermittency, frequency and decreased quality of life was associated with low CFT. Clinicians should consider screening for low T in men with cardiac problems experiencing primarily storage related symptoms. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e831-e832 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Michael Kottwitz More articles by this author Joel F. Koenig More articles by this author Bradford Stevenson More articles by this author Randy Sulaver More articles by this author Georgia Mueller More articles by this author Tobias S. Kohler More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...