PD39-01 PSA DENSITY IS CORRELATED WITH BPH CELLULAR COMPOSITION

Abstract

You have accessJournal of UrologyCME1 May 2022PD39-01 PSA DENSITY IS CORRELATED WITH BPH CELLULAR COMPOSITION Liwei Jia, Douglas Strand, Claus Roehrborn, and Ryan Mauck Liwei JiaLiwei Jia More articles by this author , Douglas StrandDouglas Strand More articles by this author , Claus RoehrbornClaus Roehrborn More articles by this author , and Ryan MauckRyan Mauck More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002597.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Current AUA guidelines suggest treatment with 5ARI for men with BPH and PSA >1.5 ng/ml. Phenotypic heterogeneity in benign prostatic hyperplasia (BPH) has been hypothesized to underlie variable response to medical therapy, but non-invasive clinical predictors of BPH cellular composition are lacking. In this study, we evaluated the stromo-glandular composition of BPH specimens for correlation with PSA density. METHODS: H&E stained sections from 132 untreated and 78 5ARI-treated BPH patients undergoing TURP or simple prostatectomy from 11/2015 to 11/2020 were scored for glandular content (Figure 1). Patients with missing PSA or prostate volume (PV) data were excluded. Univariate analysis was conducted to determine correlation of glandular content with PSA and PSA density. All analyses were performed using GraphPad Prism (v. 9.2.0). RESULTS: Prostate volume was positively correlated with PSA (P=0.0002) and the percentage of glandular content was positively correlated with PSA (P=0.0018) and PSA density (P=0.0027) in 5ARI-naive men, but not in 5ARI-treated men. CONCLUSIONS: There is strong correlation between histologic phenotype and PSA. In addition, PSA density may improve selection of patients for 5ARI medical therapy over PSA alone. Source of Funding: DK115477 (DWS) © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e652 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Liwei Jia More articles by this author Douglas Strand More articles by this author Claus Roehrborn More articles by this author Ryan Mauck More articles by this author Expand All Advertisement PDF DownloadLoading ...