PD38-12 BLADDER CANCER PROGRESSION IS ASSOCIATED WITH THE ACCUMULATION OF MDSC INDUCED BY DOWN-REGULATION OF IL6

Abstract

You have accessJournal of UrologyBladder Cancer: Basic Research & Pathophysiology III1 Apr 2016PD38-12 BLADDER CANCER PROGRESSION IS ASSOCIATED WITH THE ACCUMULATION OF MDSC INDUCED BY DOWN-REGULATION OF IL6 guoliang yang, lianhua zhang, ming cao, haige chen, and juanjie bo guoliang yangguoliang yang More articles by this author , lianhua zhanglianhua zhang More articles by this author , ming caoming cao More articles by this author , haige chenhaige chen More articles by this author , and juanjie bojuanjie bo More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.1492AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Myeloid-derived suppressor cells (MDSC) are widely implicated in immune suppression associated with tumor progression and chronic in?ammation. However, very little is known about their possible role in bladder cancer development. Here, we evaluated the role of MDSC in bladder cancer. METHODS Flow cytometry was performed on peripheral blood of 113 patients with bladder cancer and 20 healthy controls with a median follow-up of 43 months for overall survival (OS). We also assessed the expression of MDSC-inducing cytokines. RESULTS For the ?rst time, we characterized CD33-CD11b+HLA-DR- cells sorted from the peripheral blood of BC patients. CD33-CD11b+HLA-DR- cells suppressed autologous, antigen-independent T cell proliferation. The frequency of MDSC correlated with tumor grade and stage. We also showed that increased levels of circulating MDSCs correlate with reduced overall survival. Increases in the levels of pro-MDSC cytokines were observed for bladder cancer patients versus controls, and the pro-MDSC cytokine IL-6 was decreased in those patients, down-regulation of IL6 is sufficient to induce MDSC formation in vitro. CONCLUSIONS MDSC played a major role in bladder cancer progression and survival, which suggests that their targeting may provide clinical bene? ts in bladder cancer © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e929 Advertisement Copyright & Permissions© 2016MetricsAuthor Information guoliang yang More articles by this author lianhua zhang More articles by this author ming cao More articles by this author haige chen More articles by this author juanjie bo More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...