Abstract
Primary endpoints were full recovery of continence (no loss + no pads) and full recovery of EF (successful intercourse with or w/o PDE-5 inhibitors). Patients who did not reach the endpoint when the last questionnaire was filled out were censored at that time. We used Kaplan-Meier analyses with log-rank test to analyse differences in the recovery of continence and EF over time. Cox Multivariate models were fitted to assess independent predictors of EF and continence recovery. RESULTS: Median follow-up was 12.4 months for the continence endpoint and 19.0 months for the EF endpoint. Patients who underwent seLND had a lower chance of regaining both continence and EF at Kaplan-Meier analysis and multivariate analysis (HR 0.60, 95%CI 0.39e0.90, and 0.27, 95%CI 0.13e0.57, respectively). Further to the extent of the LND, age at surgery also had a significant influence on both continence and erectile function. CONCLUSIONS: Besides the unclear oncological benefits, extending the LND beyond the accepted eLND template may cause a significant delay in the recovery of urinary continence and is associated with a decreased recovery of erectile function.
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