PD36-02 TRANSPELVIC MAGNETIC STIMULATION (TPMS) AS A NOVEL THERAPY TO ENHANCE VAGINAL MICROVASCULAR PERFUSION

Abstract

You have accessJournal of UrologySexual Function/Dysfunction: Female (PD36)1 Apr 2020PD36-02 TRANSPELVIC MAGNETIC STIMULATION (TPMS) AS A NOVEL THERAPY TO ENHANCE VAGINAL MICROVASCULAR PERFUSION Samuel Sorkhi*, Minchul Cho, Sungyong Cho, Hong Chung, Christopher Cano Sanchez, Valmik Bhargava, and M. Raj Rajasekaran Samuel Sorkhi*Samuel Sorkhi* More articles by this author , Minchul ChoMinchul Cho More articles by this author , Sungyong ChoSungyong Cho More articles by this author , Hong ChungHong Chung More articles by this author , Christopher Cano SanchezChristopher Cano Sanchez More articles by this author , Valmik BhargavaValmik Bhargava More articles by this author , and M. Raj RajasekaranM. Raj Rajasekaran More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000907.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Neuromodulation using repetitive magnetic stimulation has been shown to be effective for treatment of muscular and neurological injury in several conditions, including urinary incontinence as a non-invasive and relatively painless modality. In addition, magnetic stimulation is known to improve cerebral blood flow, as well as muscle regeneration by minimizing post-injury inflammation, atrophy and scar formation. The objective of our study is to test the effect of TPMS on vaginal microcirculation in a rat model and to study the possible mechanism of action. METHODS: Female adult rats were anesthetized (n=4-5) and subjected to TPMS with simultaneous monitoring of vaginal hemodynamics (microvascular perfusion: MVP) using Laser Speckle Contrast imaging (LSCI) (Fig A). The pelvic region was placed at the center of a rat coil connected to a magnetic stimulator (Magventure; Fig A). A stimulus -response curve was established before and after periclitoral injection of L-NAME (10 mg/kg; inhibitor of nitric oxide synthase) to test involvement of nitric oxide (NO) pathway (Fig B). RESULTS: TPMS produced a stimulus dependent increase in MVP (Fig B). At 18% amplitude, TPMS produced more than a 3-fold increase in vaginal MVP from baseline (Fig B- from 40 AU to 145 AU). In addition, L-NAME injection resulted in about a 50% decrease in TPMS induced vaginal MVP increase (Fig C-D). CONCLUSIONS: Our results suggest that TPMS is a novel and non-invasive intervention to improve vaginal MVP. Potential application includes treatment of female sexual arousal dysfunction and sexual function preservation following cancer treatment, possibly through improved vaginal hemodynamics that will be beneficial to prevent possible genital tissue hypoxia and fibrosis. Our findings suggest that a TPMS induced increase in MVP is mediated by NO pathway. Future studies are warranted to confirm its utility in human subjects. Source of Funding: UCSD Academic Senate © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e723-e723 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Samuel Sorkhi* More articles by this author Minchul Cho More articles by this author Sungyong Cho More articles by this author Hong Chung More articles by this author Christopher Cano Sanchez More articles by this author Valmik Bhargava More articles by this author M. Raj Rajasekaran More articles by this author Expand All Advertisement PDF downloadLoading ...