PD36-06 EXTRAMURAL VENOUS INVASION: A NOVEL MAGNETIC RESONANCE IMAGING BIOMARKER FOR ADVERSE PATHOLOGY IN BLADDER CANCER

Abstract

You have accessJournal of UrologyCME1 Apr 2023PD36-06 EXTRAMURAL VENOUS INVASION: A NOVEL MAGNETIC RESONANCE IMAGING BIOMARKER FOR ADVERSE PATHOLOGY IN BLADDER CANCER Soroush Bazargani, Dheeraj Reddy Gopire, Ashley Way, Seyedbehzad Jazayeri, Mohammed Al-Toubat, Ahmed El-Shafie, Allison H. Feibus, Jatinder Kumar, Muhammad Umar Alam, Hariharan Palyapalayam Ganapathi, Shahriar Koochekpour, Shiva Gautam, Chandana Lall, Joseph Costa, K.C. Balaji, and Mark Bandyk Soroush BazarganiSoroush Bazargani More articles by this author , Dheeraj Reddy GopireDheeraj Reddy Gopire More articles by this author , Ashley WayAshley Way More articles by this author , Seyedbehzad JazayeriSeyedbehzad Jazayeri More articles by this author , Mohammed Al-ToubatMohammed Al-Toubat More articles by this author , Ahmed El-ShafieAhmed El-Shafie More articles by this author , Allison H. FeibusAllison H. Feibus More articles by this author , Jatinder KumarJatinder Kumar More articles by this author , Muhammad Umar AlamMuhammad Umar Alam More articles by this author , Hariharan Palyapalayam GanapathiHariharan Palyapalayam Ganapathi More articles by this author , Shahriar KoochekpourShahriar Koochekpour More articles by this author , Shiva GautamShiva Gautam More articles by this author , Chandana LallChandana Lall More articles by this author , Joseph CostaJoseph Costa More articles by this author , K.C. BalajiK.C. Balaji More articles by this author , and Mark BandykMark Bandyk More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003334.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Extramural venous invasion (EMVI) identified on magnetic resonance imaging (MRI) is a known biomarker for adverse pathology in rectal cancer, but not yet studied in bladder cancer (BCa). In this study, we explored the feasibility of identifying EMVI in patients with BCa and its utility in detecting adverse pathology. METHODS: After obtaining IRB approval, the MRI findings including EMVI were reported in consecutive BCa patients with available imaging between January 2018 and June 2020 (Figure 1). EMVI was correlated with adverse pathologic features of the pathology specimens, including lymphovascular invasion (LVI), variant histology, muscle invasive bladder cancer (MIBC), and extravesical disease (EV). Inferential statistics and logistic regression were performed for data analysis. RESULTS: A total of 38 patients were enrolled in the study, with a median age of 73 years (range 50-101). 29 (76%) patients in the study cohort were male. EMVI was identified in 23 (62%) patients. There was a significant association between EMVI and MIBC (OR=5.30, CI=1.11- 25.36; p=0.036), as well as EV (OR=17.77, CI=2.37- 133; p=0.005). There was a clear trend between EMVI and presence of LVI (OR=4.89, CI 0.92-26.1; p=0.06), as well as EMVI and histologic variant (OR=16.38 CI=0.77- 348; p=0.07) (Table 1). EMVI had sensitivity, specificity, negative predictive (NPV) and positive predictive (PPV) values of 90%, 73%, 94% and 63% respectively in detecting EV. Most interestingly, EMVI had 100% sensitivity and NPV for histologic variants. CONCLUSIONS: According to our pilot study results, EMVI, a novel imaging biomarker for BCa, is associated with adverse pathology. We propose that EMVI may be incorporated into standardized MRI reporting systems. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e982 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Soroush Bazargani More articles by this author Dheeraj Reddy Gopire More articles by this author Ashley Way More articles by this author Seyedbehzad Jazayeri More articles by this author Mohammed Al-Toubat More articles by this author Ahmed El-Shafie More articles by this author Allison H. Feibus More articles by this author Jatinder Kumar More articles by this author Muhammad Umar Alam More articles by this author Hariharan Palyapalayam Ganapathi More articles by this author Shahriar Koochekpour More articles by this author Shiva Gautam More articles by this author Chandana Lall More articles by this author Joseph Costa More articles by this author K.C. Balaji More articles by this author Mark Bandyk More articles by this author Expand All Advertisement PDF downloadLoading ...