PD36-02 INCREASED VASCULAR REMODELING AND CALCIFICATION OF CORONARY AND INTERNAL PUDENDAL ARTERIES FROM MEN WITH CARDIOVASCULAR DISEASE

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Basic Research II1 Apr 2015PD36-02 INCREASED VASCULAR REMODELING AND CALCIFICATION OF CORONARY AND INTERNAL PUDENDAL ARTERIES FROM MEN WITH CARDIOVASCULAR DISEASE Johanna L. Hannan, Jesse M. Hall, Jacob M. Fox, Patrick M. Kennedy, Mackenzie J. Clarkson, H Wayne Lambert, and Trinity J. Bivalacqua Johanna L. HannanJohanna L. Hannan More articles by this author , Jesse M. HallJesse M. Hall More articles by this author , Jacob M. FoxJacob M. Fox More articles by this author , Patrick M. KennedyPatrick M. Kennedy More articles by this author , Mackenzie J. ClarksonMackenzie J. Clarkson More articles by this author , H Wayne LambertH Wayne Lambert More articles by this author , and Trinity J. BivalacquaTrinity J. Bivalacqua More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2251AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Previous studies have improved erectile function in atherosclerotic patients by stenting the internal pudendal artery (IPA); however a third of these patients have restenosis after 6 months. In animal models, the IPA develops endothelial dysfunction, remodels and calcifies before other similar sized resistance vessels but this has not been examined in men. This study will characterize the morphology, and calcium and phosphate content of coronary arteries (CA) and IPA from male cadavers with and without cardiovascular disease (CVD). METHODS The CAs and IPAs were dissected from formalin fixed male cadavers (n=31, 49-86 years old) who had died from CVD, natural causes or cancer. Arterial segments (5mm) taken from the distal IPA (prior to dorsal artery), proximal IPA (prior to rectal artery), and CA (middle of main branch) were paraffin embedded, sectioned and stained with Masson's trichrome. Lumen diameter, wall thickness, and wall-to-lumen ratio were measured. Additional arterial segments were used to measure calcium and phosphate content. RESULTS Overall, the CA had a larger lumen diameter than the IPAs which tapered as they travelled distally towards the penis (2.6±0.18; 1.9±0.12mm; 1.2±0.09, p<0.05). The wall-to-lumen ratio was drastically increased in the distal IPA (0.84±0.28) compared to the proximal IPA (0.30±0.03) and CA (0.33±0.07). The CA from men with CVD had significantly smaller lumen diameters (2.3±0.14, 3.4±0.44mm, p<0.05) with similar wall thicknesses to men without CVD. Interestingly, both segments of the IPA were no different in morphology between men with or without CVD. This suggests that the IPAs have already undergone remodeling prior to the CAs in men without CVD. The CA calcium content was also elevated in men with CVD (0.92±0.49 vs 0.10±0.05mmol/mg, p<0.05) whereas there was no difference in the distal IPA (0.65±0.23 vs 0.44±0.14mmol/mg). The phosphate findings in all vessels paralleled the calcium content linearly. CONCLUSIONS This is the first study to characterize the morphological changes in CAs and IPAs from male cadavers. While there were obvious differences in the CA from men with and without CVDs, the IPAs from all men had similar pathological remodeling independent of underlying disease. This outlines the importance of the IPA and provides further evidence of a causative role of vascular structural changes in aging-induced erectile dysfunction. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e765 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Johanna L. Hannan More articles by this author Jesse M. Hall More articles by this author Jacob M. Fox More articles by this author Patrick M. Kennedy More articles by this author Mackenzie J. Clarkson More articles by this author H Wayne Lambert More articles by this author Trinity J. Bivalacqua More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...