PD35-05 INITIAL EXPERIENCE OF [ 177 LU]LUDOTADIPEP TREATMENT IN PATIENTS WITH [ 18 F]PSMA PET CT POSITIVE METASTATIC CASTRATION-RESISTANT PROSTATE CANCER: PRELIMINARY STUDY

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You have accessJournal of UrologyCME1 May 2022PD35-05 INITIAL EXPERIENCE OF [177LU]LUDOTADIPEP TREATMENT IN PATIENTS WITH [18F]PSMA PET CT POSITIVE METASTATIC CASTRATION-RESISTANT PROSTATE CANCER: PRELIMINARY STUDY Dongho Shin, Chang Eil Yoon, Hyeok Jae Kwon, Hyong Woo Moon, Yong Hyun Park, Woong Jin Bae, Hyuk Jin Cho, U-syn Ha, Sung-Hoo Hong, Sae Woong Kim, and Ji Youl Lee Dongho ShinDongho Shin More articles by this author , Chang Eil YoonChang Eil Yoon More articles by this author , Hyeok Jae KwonHyeok Jae Kwon More articles by this author , Hyong Woo MoonHyong Woo Moon More articles by this author , Yong Hyun ParkYong Hyun Park More articles by this author , Woong Jin BaeWoong Jin Bae More articles by this author , Hyuk Jin ChoHyuk Jin Cho More articles by this author , U-syn HaU-syn Ha More articles by this author , Sung-Hoo HongSung-Hoo Hong More articles by this author , Sae Woong KimSae Woong Kim More articles by this author , and Ji Youl LeeJi Youl Lee More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002593.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Lutetium-177 labeled prostate specific membrane antigen radio ligand therapy ([177Lu]Ludotadipep), which enables targeted delivery of beta-particle radiation to prostate cancer, has been suggested as a promising novel systemic radionuclide therapy in patients with mCRPC. METHODS: From november 2020 to august 2021, 20 men with mCRPC whom disease progressed after standard treatments were recruited for screening and 18 patients were eligible for treatment. Patient underwent a Florastamin labelled prostate specific membrane antigen positron emission tomography ([18F]PSMA PET CT) for screening to confirm high PSMA-expression. Six different patients were treated with [177Lu]Ludotadipep at doses of 50 mCi, 75 mCi and 100 mCi, respectively. [177Lu]Ludotadipep was injected via venous injection and they were hospitalized for 3 days after the injection to monitoring for any adverse effects. To evaluate the treatment outcome, serum PSA levels were followed up in 1st, 2nd, 3rd, 4th, 6th, 8th, 12th weeks and [18F]PSMA PET CT was taken in 4th and 8th weeks. RESULTS: All patients showed [18F]PSMA PET CT positive in pre [177Lu]Ludotadipep treatment. 13 (72%) underwent radical prostatectomy. 6 (33%) had received docetaxel chemotherapy. 14 (77.8%) received prior 1st and 2nd androgen deprivation therapy. 5 (27.8%) patients underwent radiotherapy (RT). In 50 mCi treated group, 40% of patients achieved PSA partial response and non-progressive disease was seen on [18F]PSMA PET CT in 60% of patients. In 75 mCi treated group, 33.3% of patients achieved PSA partial response and non-progressive disease was seen on [18F]PSMA PET CT in 100% of patients. In 100 mCi treated group, 33.3% of patients achieved PSA partial response and rest of the patient had non-progressive disease on [18F]PSMA PET CT. Only 2 patient complained transient nausea and there was no treatment related deaths. But one patient died shortly after with disease progression and could not finish the follow up. CONCLUSIONS: The current study is in the early stages of [177Lu]Ludotadipep treatment, with a final target capacity of 150 mCi. Therefore, we suggest that it could be a promising treatment with less toxicity for mCRPC patients who have not been responsive to conventional treatments. Source of Funding: None © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e629 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Dongho Shin More articles by this author Chang Eil Yoon More articles by this author Hyeok Jae Kwon More articles by this author Hyong Woo Moon More articles by this author Yong Hyun Park More articles by this author Woong Jin Bae More articles by this author Hyuk Jin Cho More articles by this author U-syn Ha More articles by this author Sung-Hoo Hong More articles by this author Sae Woong Kim More articles by this author Ji Youl Lee More articles by this author Expand All Advertisement PDF DownloadLoading ...