PD35-04 QUANTITATIVE PIFLUFOLASTAT F18 (PSMA) SCAN INDICES AS A RESPONSE IMAGING-BIOMARKER TO ANDROGEN DEPRIVATION THERAPY IN VETERANS WITH NEWLY DIAGNOSED METASTATIC PROSTATE CANCER

Abstract

You have accessJournal of UrologyCME1 May 2022PD35-04 QUANTITATIVE PIFLUFOLASTAT F18 (PSMA) SCAN INDICES AS A RESPONSE IMAGING-BIOMARKER TO ANDROGEN DEPRIVATION THERAPY IN VETERANS WITH NEWLY DIAGNOSED METASTATIC PROSTATE CANCER Nicholas Nickols, Gholam Berenji, Nathanael Kane, Karl Sjöstrand, Aseem Anand, Clayton Smith, Jeremie Calais, and Matthew Rettig Nicholas NickolsNicholas Nickols More articles by this author , Gholam BerenjiGholam Berenji More articles by this author , Nathanael KaneNathanael Kane More articles by this author , Karl SjöstrandKarl Sjöstrand More articles by this author , Aseem AnandAseem Anand More articles by this author , Clayton SmithClayton Smith More articles by this author , Jeremie CalaisJeremie Calais More articles by this author , and Matthew RettigMatthew Rettig More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002593.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Standardized quantitative assessment is necessary to associate PSMA imaging with clinical outcome and to establish its clinical utility in management of prostate cancer patients. Assessing changes in bone metastases is a particular challenge with conventional imaging modalities. In this study, we associated the quantitative changes in total PSMA tumor burden in lymph nodes and bone with that of prostate specific antigen (PSA). METHODS: Twenty-one newly diagnosed prostate cancer patients who underwent androgen deprivation therapy with or without radiation were included in this retrospective analysis. A PSMA scan was performed before initiation of treatment with androgen deprivation therapy, with or without radiation. A second PSMA scan was performed at least three months post initiation of treatment in follow-up. As recommended by E-PSMA guidelines, the quantitative metastatic disease burden (of lymph node and bone disease) relative to physiological uptake in blood pool and liver, were calculated using the PROMISE criteria. A deep learning enabled software as a medical device, known as aPROMISE, was used to locate PSMA-avid lesions and track changes over time. The continuous change in quantitative PSMA indices were compared with that of PSA. RESULTS: The DICOM PSMA PET-CT images of all twenty-one patients were successfully analyzed by aPROMISE. The median time between the baseline and post-treatment scan was 20 weeks (IQR 12 to 36 weeks). Fourteen (67%) patients had bone and/or lymph node disease, five (24%) had lymph node only disease, and two did not show metastatic PSMA avid lesions in pre-treatment scan. At treatment follow-up, patients had an average PSA response decline of 97% (median PSA 0.02). Concurrently, the changes in total PSMA indices in lymph node (average decline 80%; IQR: 62% to 100%) and in bone (average decline: 51%; IQR: 14% to 87%) were found to be significantly associated with PSA decline (r=0.74; p=0.0001). CONCLUSIONS: The study demonstrated that the change in the automated PSMA scan indices in bone and lymph node were both significantly associated to the PSA response in androgen deprivation therapy. The PSMA scan index may be a useful measurement of treatment response in bone, which is not feasible with conventional imaging. Source of Funding: Lantheus © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e628 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Nicholas Nickols More articles by this author Gholam Berenji More articles by this author Nathanael Kane More articles by this author Karl Sjöstrand More articles by this author Aseem Anand More articles by this author Clayton Smith More articles by this author Jeremie Calais More articles by this author Matthew Rettig More articles by this author Expand All Advertisement PDF DownloadLoading ...