PD35-03 THE SIGNIFICANCE OF DE-RITIS RATIO IN PATIENTS WITH RADIATION-RECURRENT PROSTATE CANCER UNDERGOING SALVAGE RADICAL PROSTATECTOMY

Abstract

You have accessJournal of UrologyCME1 May 2022PD35-03 THE SIGNIFICANCE OF DE-RITIS RATIO IN PATIENTS WITH RADIATION-RECURRENT PROSTATE CANCER UNDERGOING SALVAGE RADICAL PROSTATECTOMY Fahad Quhal, Ekaterina Laukhtina, Benjamin Pradere, Pawel Rajwa, Axel Heidenreich, and Shahrokh F. Shariat Fahad QuhalFahad Quhal More articles by this author , Ekaterina LaukhtinaEkaterina Laukhtina More articles by this author , Benjamin PradereBenjamin Pradere More articles by this author , Pawel RajwaPawel Rajwa More articles by this author , Axel HeidenreichAxel Heidenreich More articles by this author , and Shahrokh F. ShariatShahrokh F. Shariat More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002593.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To evaluate the clinical prognostic value of preoperative serum De Ritis Ratio (Aspartate aminotransferase (AST)/Alanine aminotransferase (ALT)) on postoperative survival outcomes in patients with radiation-recurrent prostate cancer who underwent salvage radical prostatectomy (SRP). METHODS: A retrospective review was conducted of patients with radiation-recurrent prostate cancer who underwent SRP in five tertiary referral centers from 2007 to 2015. An increased pre-operative serum De Ritis ratio was defined as ≥1.35. The association between De Ritis Ratio and postoperative outcomes was tested. Multivariate Cox analyses were performed to identify the independent predictors of Biochemical recurrence free survival (BCRFS), metastases free survival (MFS), overall survival (OS) and cancer specific survival (CSS). RESULTS: Overall 214 patients underwent SRP, out of them 98 (45.8%) patients with high serum De Ritis Ratio, were included in the study. In a multivariate analysis high De Ritis Ratio was an independent predictor of Biochemical Recurrence (BCR) (hazard ratio (HR) 1.79, 95% Confidence Interval (CI) 1.16-2.78, p-value 0.009) (Figure 1). No significant association was found between pre-operative DRR and MFS (HR 1.32, 95% CI 0.53-3.30, P=0.55), OS (HR 2.35, 95% CI 0.84-6.57, P=0.10) and CSS (HR 3.36, 95%CI 0.65-17.35, P=0.15). CONCLUSIONS: Increased preoperative serum DRR is associated with the development of BCR in patients with radiation-recurrent prostate cancer who underwent SRP. DRR might serve as an early indicator for BCR, which may facilitate recognition of potential relapse and could translate into more intense follow-up and even salvage therapy in selected patients. Source of Funding: No funding © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e628 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Fahad Quhal More articles by this author Ekaterina Laukhtina More articles by this author Benjamin Pradere More articles by this author Pawel Rajwa More articles by this author Axel Heidenreich More articles by this author Shahrokh F. Shariat More articles by this author Expand All Advertisement PDF DownloadLoading ...