PD33-10 PREOPERATIVE SEX HORMONES PROFILES AND PATHOLOGICAL FEATURES OF LOCALIZED PROSTATE CANCER ARE RELATED TO BOTH TOTAL AND BIOAVAILABLE TESTOSTERONE

Abstract

You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology I1 Apr 2017PD33-10 PREOPERATIVE SEX HORMONES PROFILES AND PATHOLOGICAL FEATURES OF LOCALIZED PROSTATE CANCER ARE RELATED TO BOTH TOTAL AND BIOAVAILABLE TESTOSTERONE Henry Botto, Yann Neuzillet, Marc Schneider, Morgan Rouprêt, Sarah Drouin, Marc Galiano, Xavier Cathelineau, Vincent Molinié, Camelia Radulescu, Eva Comperat, Frank Giton, Jean Fiet, Thierry Lebret, and Jean-Pierre Raynaud Henry BottoHenry Botto More articles by this author , Yann NeuzilletYann Neuzillet More articles by this author , Marc SchneiderMarc Schneider More articles by this author , Morgan RouprêtMorgan Rouprêt More articles by this author , Sarah DrouinSarah Drouin More articles by this author , Marc GalianoMarc Galiano More articles by this author , Xavier CathelineauXavier Cathelineau More articles by this author , Vincent MoliniéVincent Molinié More articles by this author , Camelia RadulescuCamelia Radulescu More articles by this author , Eva ComperatEva Comperat More articles by this author , Frank GitonFrank Giton More articles by this author , Jean FietJean Fiet More articles by this author , Thierry LebretThierry Lebret More articles by this author , and Jean-Pierre RaynaudJean-Pierre Raynaud More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.3324AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES In localized prostate cancer (PCa), impact of biochemical hypogonadism on cancer emergence and progression is still controversial. We aim to compare preoperative sex hormones plasma profiles and pathological features in localized PCa patients according to gonadal status assessed by total (TT) and bioavailable (BT). METHODS A new large prospective cohort study of 1125 (age 63.9, height 175 cm, weight 82,2 kg, BMI 26.8 30 kg/m2, waist circumference 101cm) localized PCa patients were recruited in 4 urological centre in France, from 6/2013-6/2016. Metabolic syndrome (MetS) parameters were collected. Assay of TT, BT, DHT, E1, and E2 were performed by GC-MS. A centralized cross- checked review of pathological data (Predominant Gleason pattern 4 (PrdGP4), stage) was done. RESULTS The cohort has been divided in 4 groups; the 1st group consists of patients with T and BT in the normal range (= 3 ng/ml and BT = 0,8 ng/ml), a low T in the 2nd, a low BT in the 3rd and both low T and BT in the 4th. The percentages of PrdGP4 and pT=3a were one-third in the normal gonadal patients going statistically up to one half in the hypogonadal. A 10% weight increase, due to fat, occurred in the low T patients, while no change occurred in the low BT, indicating a dichotomy in the action of T and BT. A dramatic difference in SHBG concentration between low BT and low T concentrations was observed, conferring to SHBG a key role in selecting patients at a high risk of an aggressive PCa. In fact, when considering hypogonadal patients by a threshold of TT= 3 ng/ml only, we miss 90 patients (8%) that had low BT, because of a high SHBG, no Mets but, a high %PrdG4. CONCLUSIONS Thus, a serum low BT delineate a population of aggressive PCa risk more than obesity. Consequently, for treatment decision-making, in addition to TT and obesity, BT should be assessed in the arsenal for the management of localized PCa. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e597 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Henry Botto More articles by this author Yann Neuzillet More articles by this author Marc Schneider More articles by this author Morgan Rouprêt More articles by this author Sarah Drouin More articles by this author Marc Galiano More articles by this author Xavier Cathelineau More articles by this author Vincent Molinié More articles by this author Camelia Radulescu More articles by this author Eva Comperat More articles by this author Frank Giton More articles by this author Jean Fiet More articles by this author Thierry Lebret More articles by this author Jean-Pierre Raynaud More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...