PD32-12 THE EFFECT OF TESTOSTERONE ON KIDNEY STONE RISK FACTORS

Abstract

You have accessJournal of UrologyStone Disease: Evaluation II1 Apr 2014PD32-12 THE EFFECT OF TESTOSTERONE ON KIDNEY STONE RISK FACTORS Andrew Harbin, Lauren Bakios, Fornati Bedell, John Pahira, and Gaurav Bandi Andrew HarbinAndrew Harbin More articles by this author , Lauren BakiosLauren Bakios More articles by this author , Fornati BedellFornati Bedell More articles by this author , John PahiraJohn Pahira More articles by this author , and Gaurav BandiGaurav Bandi More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.2283AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Nephrolithiasis has a two to three-fold higher prevalence in males compared to females. While the mechanism of this difference is not completely elucidated, basic science research points to the role of testosterone (T). We examine the link between serum T and stone risk factors, particularly those found in a 24-hour urine sample. METHODS We prospectively followed 35 patients with nephrolithiasis on whom serum T, free T and 24-hour urine were collected. Univariate and multivariate regression analysis were performed to find the relationship between testosterone and urinary stone risk factors. Statistical analysis was performed using SAS (Cary, NC). RESULTS Of the 35 patients who had serum T drawn, 18 patients underwent one 24-hour urine measurement. Mean total T was 341.3 (SD +/- 157.7) and mean free T was 8.3 (SD +/- 7.2) (Table 1). There was a positive correlation between urine sodium and total T (p < 0.05; Figure 1) and a positive correlation between urine oxalate and total T (p < 0.05; Figure 2). There was also a positive correlation between free T and serum creatinine (p < 0.001). CONCLUSIONS To our knowledge, this is the first study to analyze the relationship between serum T and stone risk factors in 24 hour urine samples. The positive correlation between urine oxalate, urine sodium and total T may explain the relationship between testosterone and stone risk. Correlation between 24-hour urine and serum parameters and free and total T. Value Mean Correlation with T P Value Correlation with Free T P Value Urine Creatinine (mg/day) 2053.1 +/- 562.3 0.245 0.33 -0.173 0.492 Urine Volume (ml/day) 2267.2 +/- 1101.1 -0.0307 0.90 -0.271 0.28 Urine Sodium (mg/day) 219.8+/-85.3 0.503 0.033 -0.294 0.24 Urine Calcium (mg/day) 213 +/- 59.1 -0.143 0.59 0.170 0.51 Urine Uric Acid (gm/day) 0.825 +/- 0.34 0.281 0.26 -0.385 0.12 Urine Citrate (mg/day) 631.1 +/- 339.6 -1.99 0.43 -0.426 0.078 Urine Oxalate (mg/day) 43.3 +/- 11.9 0.547 0.019 -0.0426 0.87 Urine Magnesium (mg/day) 121.5 +/- 33.4 0.153 0.54 -0.432 0.074 Urine Phosphorus (g/day) 1.19 +/- 0.32 0.311 0.21 -0.398 0.10 Urine pH 6.06 +/0 0.51 0.260 0.28 -0.285 0.24 Serum Calcium (mg/dl) 9.25 +/- 0.42 -0.100 0.567 0.0008 0.99 Serum Creatinine (mg/dl) 1.07 +/- 0.26 -0.232 0.18 0.697 0.00 Serum PTH (pg/ml) 35.0 +/- 19.6 -0.122 0.486 0.147 0.40 Serum Uric Acid (mg/dl) 6.0 +/- 1.33 -0.29 0.11 0.250 0.17 © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e840 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Andrew Harbin More articles by this author Lauren Bakios More articles by this author Fornati Bedell More articles by this author John Pahira More articles by this author Gaurav Bandi More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...