PD29-11 RELATIONSHIP BETWEEN RENAL OXYGENATION AND FUNCTION AFTER PARTIAL NEPHRECTOMY

Abstract

You have accessJournal of UrologyKidney Cancer: Surgical Therapy I1 Apr 2015PD29-11 RELATIONSHIP BETWEEN RENAL OXYGENATION AND FUNCTION AFTER PARTIAL NEPHRECTOMY Satoshi Inoue, Yasuhito Funahashi, Naoto Sassa, Yasushi Yoshino, Ryohei Hattori, and Momokazu Gotoh Satoshi InoueSatoshi Inoue More articles by this author , Yasuhito FunahashiYasuhito Funahashi More articles by this author , Naoto SassaNaoto Sassa More articles by this author , Yasushi YoshinoYasushi Yoshino More articles by this author , Ryohei HattoriRyohei Hattori More articles by this author , and Momokazu GotohMomokazu Gotoh More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.1798AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Renal hilar clamping during partial nephrectomy can cause ischemia/reperfusion injury to the surgically preserved parenchyma, which may disturb renal oxygenation after release of blood flow. In this study, we measured renal oxygenation before and after hilar clamping and investigated the association with renal function. METHODS We included 70 patients who underwent partial nephrectomy from 2009 to 2012. Thirty eight patients underwent partial nephrectomy with warm ischemia and 32 underwent partial nephrectomy with cold ischemia. Renal parenchymal arterial oxygen saturation (SaO2) was recorded before hilar clamping and 5 minutes after declamping using an Oximeter. All patients were evaluated effective renal plasma flow (ERPF) using 99mTc-MAG3 renal scintigraphy before surgery. RESULTS Pearson□fs correlation coefficient showed a significant correlations between baseline SaO2 and both eGFR (p = 0.003) and ERPF (p < 0.001). The SaO2 decreased by 6.1% and 17.0% after the release of clamping in the warm and cold ischemia groups, respectively. The eGFR decreased by 18.3% and 12.1% after surgery, respectively. There was a significant correlation between the change of SaO2 and ischemic time only in the warm ischemia group (p = 0.042), but not in the cold ischemia group (p = 0.924). There was also a significant association between the change of SaO2 and eGFR (%) in the warm ischemia group (p = 0.029), but not in the cold ischemia group (p = 0.537). CONCLUSIONS The decrease in renal oxygenation was significantly correlated with warm ischemic time and renal functional loss after partial nephrectomy. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e653 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Satoshi Inoue More articles by this author Yasuhito Funahashi More articles by this author Naoto Sassa More articles by this author Yasushi Yoshino More articles by this author Ryohei Hattori More articles by this author Momokazu Gotoh More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...