PD29-11 EVALUATION OF SARS-COV-2 IN HUMAN SEMEN AND EFFECT ON TOTAL SPERM NUMBER: A PROSPECTIVE OBSERVATIONAL STUDY

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You have accessJournal of UrologyInfertility: Epidemiology & Evaluation II (PD29)1 Sep 2021PD29-11 EVALUATION OF SARS-COV-2 IN HUMAN SEMEN AND EFFECT ON TOTAL SPERM NUMBER: A PROSPECTIVE OBSERVATIONAL STUDY Jordan Best, Manish Kuchakulla, Kajal Khodamoradi, Thiago Lima, Fabio Frech, Justin Achua, Omar Rosete, Belen Mora, Himanshu Arora, Emad Ibrahim, and Ranjith Ramasamy Jordan BestJordan Best More articles by this author , Manish KuchakullaManish Kuchakulla More articles by this author , Kajal KhodamoradiKajal Khodamoradi More articles by this author , Thiago LimaThiago Lima More articles by this author , Fabio FrechFabio Frech More articles by this author , Justin AchuaJustin Achua More articles by this author , Omar RoseteOmar Rosete More articles by this author , Belen MoraBelen Mora More articles by this author , Himanshu AroraHimanshu Arora More articles by this author , Emad IbrahimEmad Ibrahim More articles by this author , and Ranjith RamasamyRanjith Ramasamy More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002030.11AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The severe acute-respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has created a surge of research to help better understand the breadth of possible sequelae. However, little is known regarding the impact on semen parameters and fertility potential. Our study sought to evaluate the impact of SARS-CoV-2 on male reproduction among American men. We collected semen samples from men who recovered from SARS-CoV-2 infection to evaluate for the presence of SARS-CoV-2. We also assessed the impact of SARS-CoV-2 infection on total sperm number (TSN) in ejaculate both during the acute phase after testing positive and a smaller cohort of men at follow-up. METHODS: We prospectively recruited thirty men diagnosed with acute SARS-CoV-2 infection using real-time reverse transcriptase-polymerase chain reaction (RT-PCR) of pharyngeal swab specimens. Semen samples were collected from each individual using mailed kits. Follow-up semen samples were done with mailed kits or in-person in office setting. Semen analysis and PCR was performed after samples were received. RESULTS: Thirty semen samples from recovered men were obtained 11-64 days after testing positive for SAR-CoV-2 infection. The median duration between positive SAR-CoV-2 test and semen collection was 37 days (IQR=23). The median total sperm number (TSN) in ejaculate was 12.5 million (IQR=53.1). When compared with age-matched SARS-CoV-2(-) men, TSN was lower among SARS-CoV-2(+) men (p=0.0024). Five men completed a follow-up sperm analysis (median 3 months) and had a median TSN of 18 million (IQR=21.6). No RNA was detected by means of RT-PCR in the semen in 16 samples tested. CONCLUSIONS: SARS-CoV-2 infection, though not detected in semen of recovered men, can affect TSN in ejaculate in the acute setting. Whether SARS-CoV-2 can affect spermatogenic function long-term remains to be evaluated. Source of Funding: University of Miami Department of Urology © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e530-e531 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jordan Best More articles by this author Manish Kuchakulla More articles by this author Kajal Khodamoradi More articles by this author Thiago Lima More articles by this author Fabio Frech More articles by this author Justin Achua More articles by this author Omar Rosete More articles by this author Belen Mora More articles by this author Himanshu Arora More articles by this author Emad Ibrahim More articles by this author Ranjith Ramasamy More articles by this author Expand All Advertisement PDF downloadLoading ...