Abstract
detected pulmonary embolism) and timing of TEE (before or after ( 30 days) RC) and Khorana score (established for cancer patients treated with chemotherapy, based on baseline hemoglobin, platelet and leukocyte counts, BMI and tumor site) was determined for all patients. All patients received TEE prophylaxis during the early post-RC period. Multivariate analysis was performed on 827 patients. Kaplan Meier survival curves and log rank test were used to compare survival between patients who developed TEE and those who did not. RESULTS: The Khorana criteria indicated intermediate TEE risk in most patients. Khorana risk score was 1 or 2 in 88% of patients. Overall, the incidence of TEE in patients was 15%. 59 TEE were detected pre-operatively (7.1%), 21 early within 30 days of RC (2.5%) and 36 late post-operatively (4.3%). 32% of the TEE events were detected incidentally by imaging, 68% were detected clinically. Median overall survival of patients who developed TEE was 28 months compared to 71 months for those who did not develop TEE (p1⁄40.012). CONCLUSIONS: This multi-centre retrospective study suggests that TEE are very common in bladder cancer patients undergoing NAC before and after RC and they associate with poorer survival. Further investigation with a prospective prevention trial for the period of NAC is warranted.
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