PD27-02 WIRELESS CATHETER-FREE AMBULATORY URODYNAMICS FOR BLADDER PHYSIOLOGY RESEARCH

Abstract

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Basic Research & Pathophysiology (PD27)1 Sep 2021PD27-02 WIRELESS CATHETER-FREE AMBULATORY URODYNAMICS FOR BLADDER PHYSIOLOGY RESEARCH Maxx Caveney, Steve Majerus, Kangli Deng, Brett Hanzlicek, Binit Panda, James Mrowca, Dennis Bourbeau, and Margot Damaser Maxx CaveneyMaxx Caveney More articles by this author , Steve MajerusSteve Majerus More articles by this author , Kangli DengKangli Deng More articles by this author , Brett HanzlicekBrett Hanzlicek More articles by this author , Binit PandaBinit Panda More articles by this author , James MrowcaJames Mrowca More articles by this author , Dennis BourbeauDennis Bourbeau More articles by this author , and Margot DamaserMargot Damaser More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002020.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: As with clinical urodynamics, investigations into lower urinary tract physiology using animal models require catheter-based systems to measure bladder pressure while filling the bladder, often under anesthesia. However, anesthesia, catheters and filling of the bladder can affect filling pressures, urinary leakage and voiding reflexes. To enable recordings more representative of normal physiology, we developed a catheter-free, wireless, intravesical sensor which is implanted in the feline bladder lumen and wirelessly transmits bladder pressure and volume data. We validated sensor function by recording volume and pressure over 4-week implantations in felines. METHODS: The Urological Monitor of Conscious Activity (UroMOCA) measures 18x12x5.6 mm and wirelessly transmits data to a radio and antenna placed in an animal backpack. The UroMOCA battery can be recharged wirelessly via a charging mat placed under the subject. Platinum electrodes measuring urine concentration and conductance estimate urine volume and are paired with an onboard pressure sensor. Under anesthesia, a UroMOCA was implanted into the bladder lumen via cystotomy in male felines. Baseline cystometry was performed and CT imaged the UroMOCA in the bladder. Anesthetized cystometry with UroMOCA recording and imaging were repeated 2 and 4 weeks post-implantation. Ambulatory recordings were performed multiple times for up to two hours per session during the four weeks prior to device explantation. Sham surgeries and sham devices were implanted in some animals to assess the impact of the UroMOCA on the bladder. RESULTS: 10 feline cats were enrolled: 3 were sham implants (no device), 1 received an inactive device, and 6 received a functional UroMOCA. Non-anesthetized recordings were performed for a total 2,899 minutes over 33 ambulatory sessions. After 2 weeks, all animals resumed normal voiding volume. Urinary retention requiring intermittent catheterization was seen in 1 feline; there was no evidence of obstruction. Wireless pressure data linearly correlated with anesthetized cystometry (R2=0.96). Volume measurement was variable but decreased during voiding and increased during filling. Histology showed normal bladder tissue. CONCLUSIONS: A small, wireless, catheter-free, intravesical sensor enabled conscious recordings of bladder function in felines during natural bladder filling over 4 weeks. The volume sensor enabled differentiation of an empty from a full bladder. Source of Funding: This work was funded by the NIH Stimulating Peripheral Activity to Relieve Conditions (SPARC) program, NIH grant number OT2OD023873 © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e443-e444 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Maxx Caveney More articles by this author Steve Majerus More articles by this author Kangli Deng More articles by this author Brett Hanzlicek More articles by this author Binit Panda More articles by this author James Mrowca More articles by this author Dennis Bourbeau More articles by this author Margot Damaser More articles by this author Expand All Advertisement Loading ...