PD27-02 99m TC-PSMA RADIOGUIDED SURGERY USING A DROP-IN GAMMA PROBE IN RADICAL PROSTATECTOMY: INITIAL RESULTS

Abstract

You have accessJournal of UrologyCME1 Apr 2023PD27-02 99mTC-PSMA RADIOGUIDED SURGERY USING A DROP-IN GAMMA PROBE IN RADICAL PROSTATECTOMY: INITIAL RESULTS Nina Harke, Christian Fuhrmann, Thorsten Derlin, Desiree Weiberg, Olga Katzendorn, Christoph Czerner, Frank Rudolf, Tobias Ross, Hossein Tezval, and Markus A. Kuczyk Nina HarkeNina Harke More articles by this author , Christian FuhrmannChristian Fuhrmann More articles by this author , Thorsten DerlinThorsten Derlin More articles by this author , Desiree WeibergDesiree Weiberg More articles by this author , Olga KatzendornOlga Katzendorn More articles by this author , Christoph CzernerChristoph Czerner More articles by this author , Frank RudolfFrank Rudolf More articles by this author , Tobias RossTobias Ross More articles by this author , Hossein TezvalHossein Tezval More articles by this author , and Markus A. KuczykMarkus A. Kuczyk More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003305.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: In the recent years, PSMA-based diagnostics and therapy has become increasingly established with the addition of radioguided surgery (RGS) and the intraoperative detection of radioactively labeled lymph nodes. We present the first results of a new robotic drop-in gamma probe (SENSEI®; Lightpoint Medical) for the detection of 99mTc-PSMA in robot-assisted radical prostatectomy (RARP). METHODS: The data of nine patients with prostate cancer undergoing RGS were evaluated retrospectively. After preoperative administration of 99mTc-PSMA, a SPECT-CT was conducted and a robotic radical prostatectomy was performed the following day including intraoperative measurement of the lymph node stations using SENSEI®. This was followed by a robotic extended pelvic lymph node dissection with ex vivo control measurement using SENSEI® and a conventional gamma probe. RESULTS: With a mean PSA value of 12.2 ng/ml, seven patients had high-risk and two patients had intermediate-risk prostate cancer. The SPECT-CT examination carried out preoperatively showed no findings suspicious for metastases in eight patients. The in- and ex-vivo lymph node measurements did not show a count rate that was significantly higher than the background. In one patient, intra- and postoperative measurement confirmed the positive signal found on SPECT-CT with lymph node metastases in the final histopathology results. Overall, a mean of 22 lymph nodes were dissected. No postoperative complications related to 99mTc-PSMA RGS or extended pelvic lymph node dissection occurred. CONCLUSIONS: 99mTc-PSMA RGS with SENSEI® allows for safe and easy lymph node measurements during surgery with no false-negative nor false-positive findings so far. Data from further patients will have to confirm these initial results. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e741 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Nina Harke More articles by this author Christian Fuhrmann More articles by this author Thorsten Derlin More articles by this author Desiree Weiberg More articles by this author Olga Katzendorn More articles by this author Christoph Czerner More articles by this author Frank Rudolf More articles by this author Tobias Ross More articles by this author Hossein Tezval More articles by this author Markus A. Kuczyk More articles by this author Expand All Advertisement PDF downloadLoading ...