PD26-01 A PROSPECTIVE, RANDOMIZED, SINGLE-BLIND COMPARISON OF URETERAL STENT BIOMATERIAL ENCRUSTATION

Abstract

You have accessJournal of UrologyStone Disease: Surgical Therapy III (PD26)1 Sep 2021PD26-01 A PROSPECTIVE, RANDOMIZED, SINGLE-BLIND COMPARISON OF URETERAL STENT BIOMATERIAL ENCRUSTATION Shuzo Hamamoto, Ryosuke Chaya, Masahiko Isogai, Kengo Kawase, Tomoki Okada, Tatsuya Hattori, Teruaki Sugino, Rei Unno, Kazumi Taguchi, Atsushi Okada, and Takahiro Yasui Shuzo HamamotoShuzo Hamamoto More articles by this author , Ryosuke ChayaRyosuke Chaya More articles by this author , Masahiko IsogaiMasahiko Isogai More articles by this author , Kengo KawaseKengo Kawase More articles by this author , Tomoki OkadaTomoki Okada More articles by this author , Tatsuya HattoriTatsuya Hattori More articles by this author , Teruaki SuginoTeruaki Sugino More articles by this author , Rei UnnoRei Unno More articles by this author , Kazumi TaguchiKazumi Taguchi More articles by this author , Atsushi OkadaAtsushi Okada More articles by this author , and Takahiro YasuiTakahiro Yasui More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002019.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Ureteral stents are commonly used in endoscopic surgery for urinary calculi but are frequently associated with stent encrustation and stent-related infections. New biomaterials and coatings have been designed to overcome these disadvantages. However, there are no real-world reports comparing biomaterial encrustation of different stents. In this study, we prospectively evaluated the adherence of bacteria, Ca, and Mg to three different ureteral stents after endoscopic surgery for urinary calculi. METHODS: A total of 61 patients requiring insertion of ureteral stents after the treatment of urinary calculi were randomly placed into 3 groups [PercuflexⓇ with a coating composition of Hydroplus, Group 1 (n=21); Tria, with a coating composition of PercushiedⓇ, Group 2 (n=22); InLay OptimaⓇ, which had a proprietary pHreeCoat coating, Group 3 (n=18)]. All stents were removed one month after treatment and evaluated. A stent was immersed in a solution of saline and hydrochloric acid at pH 2 and subsequently vortexed for one hour. Ca and Mg contents were measured using atomic absorption spectrometry. Bacteria were measured using flow cytometry. RESULTS: There were no significant differences about patients and stone characteristics. The incidence of stone encrustation was significantly higher in Group 1 than in Groups 2 and 3 (33.3%, 11.7%, and 7.7%, respectively; p=0.02). The median amount (IQR) of Ca adhered to the stents in Group 1 was significantly higher than that in Groups 2 and 3 (5.51 (2.28-6.18), 1,91 (0.53-4.48), 2.30 (0.76-3.03) mg/dL respectively, p=0.024). The median amount (IQR) of Mg in Group 1 was significantly higher than that in Groups 2 and 3 (0.20 (0.15-0.23), 0.06 (0.04-0.20), 0.03 (0.03-0.13) mg/dL respectively, p=0.005). The median number (IQR) of bacteria was also highest in Group 1 (33.76 (23.13-109.43), 13.80 (6.23-56.25), 8.33 (6.80-21.20), respectively, p=0.056); however, there were no significant differences in bacterial adhesion. CONCLUSIONS: This randomized study showed that stents with Percusheild coating and pHreeCoat coating decreased the adherence of Ca, Mg after endoscopic treatment. These stents could reduce stent encrustation and stent-related infections. Source of Funding: none © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e437-e437 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Shuzo Hamamoto More articles by this author Ryosuke Chaya More articles by this author Masahiko Isogai More articles by this author Kengo Kawase More articles by this author Tomoki Okada More articles by this author Tatsuya Hattori More articles by this author Teruaki Sugino More articles by this author Rei Unno More articles by this author Kazumi Taguchi More articles by this author Atsushi Okada More articles by this author Takahiro Yasui More articles by this author Expand All Advertisement Loading ...