PD25-04 AZOOSPERMIA IS NOT ASSOCIATED WITH INCREASED RISK OF MORTALITY OR CANCER DIAGNOSIS

Abstract

You have accessJournal of UrologyInfertility: Epidemiology & Evaluation II (PD25)1 Apr 2020PD25-04 AZOOSPERMIA IS NOT ASSOCIATED WITH INCREASED RISK OF MORTALITY OR CANCER DIAGNOSIS Sorena Keihani*, Ashlynn Sandberg, Chong Zhang, Angela Presson, Heidi Hanson, Stevie Kinnear, Kenneth Aston, Ken Smith, Douglas Carrell, Alexander Pastuszak, and James Hotaling Sorena Keihani*Sorena Keihani* More articles by this author , Ashlynn SandbergAshlynn Sandberg More articles by this author , Chong ZhangChong Zhang More articles by this author , Angela PressonAngela Presson More articles by this author , Heidi HansonHeidi Hanson More articles by this author , Stevie KinnearStevie Kinnear More articles by this author , Kenneth AstonKenneth Aston More articles by this author , Ken SmithKen Smith More articles by this author , Douglas CarrellDouglas Carrell More articles by this author , Alexander PastuszakAlexander Pastuszak More articles by this author , and James HotalingJames Hotaling More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000882.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Infertile men might have higher risk of comorbidities, although the associations between semen quality and health conditions are inconsistent. We aimed to study the overall risk of cancer and mortality in azoospermic men using a population-based cohort of men undergoing infertility evaluation. METHODS: We used a cohort of subfertile men from 1996-2017 that was linked to the Utah Population Database. Demographics and baseline semen parameters were extracted, and statewide records screened to capture non-skin cancer diagnoses and all-cause mortality during the study period or until the last date of residence in Utah. Vasectomy patients and those with a cancer diagnosis prior to semen analysis were excluded. Patients were categorized based on sperm concentration as azoospermic, oligozoospermic (<15 M/ml), and normozoospermic (≥15 M/ml). A control group with proven fertility, matched by birth year, was selected at a 1:5 ratio to the azoospermic group. Cox proportional hazard ratios were used to compare time-to-events between azoospermic men and controls (model-1) as well as oligo- and normozoospermic men (model-2) after controlling for birth year and smoking status. RESULTS: A total of 21,098 men were included with 619 azoospermic, 3,026 controls, 2,215 oligozoospermic, and 15,239 normozoospermic men. Mean age of azoospermic men was 34.0±8.0 years with a median of 9.0 y (95% CI: 8.4–9.6) follow up. Overall, 25 (4%) and 117 (4%) deaths were observed among azoospermic men and controls, respectively. Mean age of death was 51.3±17 y in the azoospermic men and 53.4±13.8 y in controls. During the study period, 22 (4%) azoospermic patients and 115 (4%) controls were diagnosed with cancer at a mean age of 51.7±13.6 and 54.1±10.8 y, respectively. Risk of all-cause mortality or cancer was not significantly different between azoospermic men and controls. Neither azoospermic nor oligozoospermic men had increased risk of mortality or cancer when compared to normozoospermic men after controlling for age and smoking status (Table). CONCLUSIONS: In the present analysis, azoospermia was not associated with higher mortality or cancer risk. Further investigation is needed to assess the association between azoospermia, cancer and other causes of mortality in larger cohorts. Source of Funding: None © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e539-e539 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Sorena Keihani* More articles by this author Ashlynn Sandberg More articles by this author Chong Zhang More articles by this author Angela Presson More articles by this author Heidi Hanson More articles by this author Stevie Kinnear More articles by this author Kenneth Aston More articles by this author Ken Smith More articles by this author Douglas Carrell More articles by this author Alexander Pastuszak More articles by this author James Hotaling More articles by this author Expand All Advertisement PDF downloadLoading ...