PD25-02 RELATIONSHIP BETWEEN SEMEN PARAMETERS AND ASSISTED REPRODUCTIVE TECHNOLOGY OUTCOMES

Abstract

You have accessJournal of UrologyInfertility: Epidemiology & Evaluation II (PD25)1 Apr 2020PD25-02 RELATIONSHIP BETWEEN SEMEN PARAMETERS AND ASSISTED REPRODUCTIVE TECHNOLOGY OUTCOMES Alex Kasman*, Shufeng Li, Barry Behr, and Michael Eisenberg Alex Kasman*Alex Kasman* More articles by this author , Shufeng LiShufeng Li More articles by this author , Barry BehrBarry Behr More articles by this author , and Michael EisenbergMichael Eisenberg More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000882.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Infertility is associated with adverse perinatal and neonatal outcomes regardless of assisted reproductive technology (ART). Prior studies have identified a possible relationship between a man’s health and ART outcomes. Despite this, few studies have analyzed the association between ART outcomes and semen quality. We sought to examine ART outcomes (fertilization rate, implantation rate, blast formation, pregnancy rate, embryo aneuploidy, etc.) and perinatal outcomes (birth weight, gestational age) in relation to semen parameters and paternal age. METHODS: This retrospective cohort study was carried out on all ART cycles at an academic reproductive medicine center utilizing freshly ejaculated sperm from the male partner of couples undergoing ART cycles from 2012-2016. During this period of time, there were no changes to laboratory or clinical protocols and only multi-step medium were used. Semen parameters (volume, concentration, motility, total motile count (TMC)) were stratified based on WHO 5th edition criteria. We assessed the association between semen quality, paternal age (< or ≥40), and reproductive/perinatal outcomes by GEE or linear mixed model to account for some couples had multiple cycles. All tests were adjusted for maternal age and treatment year. Fertilization rate, implantation rate, blast formation rate, and gestational age were dichotomized due to abnormal distribution. Statistical analysis was carried out utilizing SAS version 9.4 (SAS Institute Inc., Cary, NC). RESULTS: In all, 1426 couples were identified who underwent 2310 ART cycles. The average ages of the male and female partners were 40.2 and 38.1, respectively. A lower motility (i.e. <40%) was associated with lower successful in vitro fertilization (IVF) outcomes including lower implantation rate (13 vs 20%, p <0.01), higher miscarriage (54 vs 38%, p = 0.01), and lower live birth rate (46 vs 59%, p=0.04). When examining only cycles utilizing ICSI, lower implantation rate (11 vs 20%, p <0.01) and miscarriage rate (58 vs 39%, p = 0.04) were similarly noted when motility was less than 40%. No association was identified between semen quality and gestational age or birth weight. While age ≥40 years was associated with abnormal embryo biopsy results (67 vs 50%, p = 0.046), semen quality was found to be not associated with abnormal embryo biopsy results. CONCLUSIONS: The current study reports an association between sperm motility and IVF outcomes including implantation rate, miscarriage rate, and live birth rate. Advanced paternal age may negatively impact embryo biopsy results however does not appear significantly affect other IVF and ICSI outcomes. These results may lead to improved ART counseling for couples especially for those with poor sperm motility. Source of Funding: None © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e538-e538 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Alex Kasman* More articles by this author Shufeng Li More articles by this author Barry Behr More articles by this author Michael Eisenberg More articles by this author Expand All Advertisement PDF downloadLoading ...