PD24-11 COMPARISON OF INTRACYTOPLASMIC SPERM INJECTION (ICSI) OUTCOMES BETWEEN EJACULATED AND TESTICULAR EXTRACTED SPERMATOZOA IN COUPLES WITH RECURRENT IMPLANTATION FAILURE

Abstract

You have accessJournal of UrologyInfertility: Therapy1 Apr 2014PD24-11 COMPARISON OF INTRACYTOPLASMIC SPERM INJECTION (ICSI) OUTCOMES BETWEEN EJACULATED AND TESTICULAR EXTRACTED SPERMATOZOA IN COUPLES WITH RECURRENT IMPLANTATION FAILURE Mehmet Murad Basar, Nur Dokuzeylul-Gungor, Mehmet Ali Tufekci, Yesim Kumtepe-Colakoglu, Tugba Senel, and Semra Kahraman Mehmet Murad BasarMehmet Murad Basar More articles by this author , Nur Dokuzeylul-GungorNur Dokuzeylul-Gungor More articles by this author , Mehmet Ali TufekciMehmet Ali Tufekci More articles by this author , Yesim Kumtepe-ColakogluYesim Kumtepe-Colakoglu More articles by this author , Tugba SenelTugba Senel More articles by this author , and Semra KahramanSemra Kahraman More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.2002AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Testicular sperm usage is an alternative method for patients associated with lower fertilization and embryo cleavage rates in their previous ICSI with mature ejaculated sperm. The aim of the present study is to compare ICSI outcomes of couples with recurrent implantation failure after use of ejaculated versus testicular spermatozoa with different cycles in the same centre. METHODS This study included 140 ART cycles in 51 couples. Patients were divided into two groups according to source of spermatozoa. Group 1 included of 76 cycles using ejaculated spermatozoa in our center. If the patients had at least twice ICSI cycle with ejaculated spermatozoa and/or had total severe immotile sperm (no progressive motility), testicular spermatozoa was obtained with testicular sperm aspiration (TeSa) under local anesthesia in 64 cycles of group 2. Fertilization, embryo quality and clinical pregnancy rates were compared between groups. RESULTS Mean age of males and women were 38.2±7 (24-58) and 33.5±5.9 (21-44) years old, respectively. Previous ICSI cycles were 3.2±2.6 in ejaculated spermatozoa used patients and 3.4±2.4 in testicular spermatozoa used patients (p=0.279). In Group 1, total oocyte number and MII oocyte number were 8.9.±7.9 and 6.8±6. These parameters were10.5±7.4 and 8.2±6.1 in group 2, respectively. There were not found statistical difference between two groups according to these parameters (ptotaloocysts = 0.111; pMIIoocyts = 0.078). While fertilization rate was higher with ejaculated spermatozoa (79.3%) than testicular spermatozoa (74.9%) (p=0.103), pregnancy rate was statistically higher with testicular spermatozoa than ejaculated spermatozoa (41.7% vs 21.4%, respectively, p=0.021). Additionaly, ongoing pregnancy rate (OPR) and takehome baby rate (THBR) were higher with testicular spermatozoa than ejaculated spermatozoa (OPR: 26.7% vs 7.1%, p= 0.006; THBR: 24.6% vs 6.0%, p= 0,008). There were observed no complications after TESA in patients such as hematoma, pain etc. CONCLUSIONS ICSI cycle with testicular sperm is one of the best choices in idiopathic male fertility resulting in ICSI cycle failure with ejaculated sperm, and can have marked improvement in outcome. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e734 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Mehmet Murad Basar More articles by this author Nur Dokuzeylul-Gungor More articles by this author Mehmet Ali Tufekci More articles by this author Yesim Kumtepe-Colakoglu More articles by this author Tugba Senel More articles by this author Semra Kahraman More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...