PD24-08 WIRELESS IMPLANTABLE RECHARGEABLE BLADDER PRESSURE SENSOR: CYSTOSCOPIC IMPLANTATION AND AMBULATORY DATA COLLECTION

Abstract

You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Incontinence: Evaluation (Urodynamic Testing)1 Apr 2015PD24-08 WIRELESS IMPLANTABLE RECHARGEABLE BLADDER PRESSURE SENSOR: CYSTOSCOPIC IMPLANTATION AND AMBULATORY DATA COLLECTION Iryna Makovey, Steve Majerus, Robert Karam, Brett Hanzlicek, Matthew Streicher, Hui Zhu, and Margot Damaser Iryna MakoveyIryna Makovey More articles by this author , Steve MajerusSteve Majerus More articles by this author , Robert KaramRobert Karam More articles by this author , Brett HanzlicekBrett Hanzlicek More articles by this author , Matthew StreicherMatthew Streicher More articles by this author , Hui ZhuHui Zhu More articles by this author , and Margot DamaserMargot Damaser More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.1463AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES There is a need for a minimally invasive chronic bladder pressure-monitoring sensor both for better diagnosis of voiding dysfunction and to be used as a feedback mechanism for neurostimulation. We have developed a miniature wireless implantable micromanometer (WIMM) system designed for cystoscopic sub-mucosal implantation. This system is capable of wireless real time data transmission, wireless battery recharging, and ambulatory bladder pressure data collection. METHODS A WIMM device measuring 6.8 × 3.0 × 15 mm was cystoscopically implanted into a sub-urothelial pocket posterior to the trigone in a female calf model. Cautery was used to nick the mucosa and 1.5 cc 5Fr arterial embolectomy catheter was used to develop the sub-urothelial plane. The WIMM was inserted through the 26Fr rigid cystoscope sheath directly into the pocket. Catheter based urodynamic study was performed while data was recorded simultaneously from the WIMM sensor via wireless data transmission to an external receiver. Manual compressions were conducted during bladder filling as an additional test for the implanted device. Post-operatively data was collected with the WIMM sensor while calves were conscious and standing, laying down, ambulating, or experiencing bladder contractions. Implanted WIMM devices were recharged wirelessly every few days via an external charger. RESULTS Device placement was successfully performed in two female calves. A CT cystogram was performed prior to and after device placement. No contrast extravasation was observed and device location was confirmed posterior to the trigone. We achieved device retention at least 2 weeks after implantation. Data was collected wirelessly with the WIMM device in both anesthetized and conscious ambulatory situations. The correlation coefficient to reference catheter based pressure recording was 0.82. The implanted WIMM pressure sensor was able to detect bladder events such as manual compressions, position changes, movement artifact, and bladder contractions. CONCLUSIONS We have demonstrated the safety and feasibility of minimally invasive cystoscopic implantation of a miniature implantable wireless bladder pressure sensor. Data was successfully collected from anesthetized urodynamics and ambulatory recordings in a calf animal model using the WIMM sensor. This device has the potential for use both for chronic bladder monitoring and for wireless feedback to an electrical stimulation system. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e489 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Iryna Makovey More articles by this author Steve Majerus More articles by this author Robert Karam More articles by this author Brett Hanzlicek More articles by this author Matthew Streicher More articles by this author Hui Zhu More articles by this author Margot Damaser More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...