PD24-07 FIRST ANALYSIS OF THE SAFETY AND EFFICACY OF UGN-101 IN THE TREATMENT OF URETERAL TUMORS

Abstract

You have accessJournal of UrologyCME1 Apr 2023PD24-07 FIRST ANALYSIS OF THE SAFETY AND EFFICACY OF UGN-101 IN THE TREATMENT OF URETERAL TUMORS Joseph Jacob, Solomon Woldu, Jennifer Linehan, Craig Labbate, Kyle Rose, Wade Sexton, Isamu Tachibana, Hristos Kaimakliotis, Alan Nieder, Marc Bjurlin, Mitchell Humphreys, Saum Ghodoussipor, Marcus Quek, Michael O'Donell, Brian Eisner, Adam Feldman, Katie Murray, Serena Matin, Yair Lotan, and Rian Dickstein Joseph JacobJoseph Jacob More articles by this author , Solomon WolduSolomon Woldu More articles by this author , Jennifer LinehanJennifer Linehan More articles by this author , Craig LabbateCraig Labbate More articles by this author , Kyle RoseKyle Rose More articles by this author , Wade SextonWade Sexton More articles by this author , Isamu TachibanaIsamu Tachibana More articles by this author , Hristos KaimakliotisHristos Kaimakliotis More articles by this author , Alan NiederAlan Nieder More articles by this author , Marc BjurlinMarc Bjurlin More articles by this author , Mitchell HumphreysMitchell Humphreys More articles by this author , Saum GhodoussiporSaum Ghodoussipor More articles by this author , Marcus QuekMarcus Quek More articles by this author , Michael O'DonellMichael O'Donell More articles by this author , Brian EisnerBrian Eisner More articles by this author , Adam FeldmanAdam Feldman More articles by this author , Katie MurrayKatie Murray More articles by this author , Serena MatinSerena Matin More articles by this author , Yair LotanYair Lotan More articles by this author , and Rian DicksteinRian Dickstein More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003302.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: UGN-101 has been approved for the chemoablation of low-grade upper tract urothelial cancer (UTUC) involving the renal pelvis and calyces. Herein is the first reported cohort of patients with ureteral tumors treated with UGN-101. METHODS: We performed a retrospective review of patients treated with UGN-101 at 15 high volume centers and compare outcomes of those with ureteral tumors with or without renal pelvis tumors and those with only renal pelvis tumors. Efficacy endpoints were evaluated via results at first endoscopic evaluation as well as rates of recurrence and progression. Adverse outcomes were characterized with a focus on the rate of ureteral stenosis. RESULTS: In a cohort of 132 patients and 136 renal units, 47 cases had tumor involvement of the ureter, with 12 cases of ureteral tumor only (8.8%) and 35 cases of ureteral plus renal pelvic tumors (25.7%). There was no difference in outcomes at first endoscopic evaluation between cases involving the ureter versus cases without ureteral involvement (p=0.644). There was also no difference in recurrence rate or progression based on tumor location. Fourteen patients (37.8%) with ureteral tumor had significant ureteral stenosis at first post-treatment evaluation, however, when excluding those with pre-existing hydronephrosis or ureteral stenosis, only 5.4% of patients developed new clinically significant stenosis. CONCLUSIONS: UGN-101 appears to be equally safe and efficacious in treating low grade urothelial carcinoma of the ureter as compared to renal pelvic tumors. Source of Funding: none © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e724 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Joseph Jacob More articles by this author Solomon Woldu More articles by this author Jennifer Linehan More articles by this author Craig Labbate More articles by this author Kyle Rose More articles by this author Wade Sexton More articles by this author Isamu Tachibana More articles by this author Hristos Kaimakliotis More articles by this author Alan Nieder More articles by this author Marc Bjurlin More articles by this author Mitchell Humphreys More articles by this author Saum Ghodoussipor More articles by this author Marcus Quek More articles by this author Michael O'Donell More articles by this author Brian Eisner More articles by this author Adam Feldman More articles by this author Katie Murray More articles by this author Serena Matin More articles by this author Yair Lotan More articles by this author Rian Dickstein More articles by this author Expand All Advertisement PDF downloadLoading ...