PD24-07 EFFECTS OF MEDICAL TREATMENT AND THE SEX STEROID LEVELS ON TESTICULAR SPERM RETRIEVAL RATE IN KLINEFELTER SYNDROME

Abstract

You have accessJournal of UrologyInfertility: Therapy1 Apr 2014PD24-07 EFFECTS OF MEDICAL TREATMENT AND THE SEX STEROID LEVELS ON TESTICULAR SPERM RETRIEVAL RATE IN KLINEFELTER SYNDROME Mehmet Murad Basar, Nur Dokuzeylul-Gungor, Yesim Kumtepe-Colakoglu, Serkan Selimoglu, Erdal Alkan, and Semra Kahraman Mehmet Murad BasarMehmet Murad Basar More articles by this author , Nur Dokuzeylul-GungorNur Dokuzeylul-Gungor More articles by this author , Yesim Kumtepe-ColakogluYesim Kumtepe-Colakoglu More articles by this author , Serkan SelimogluSerkan Selimoglu More articles by this author , Erdal AlkanErdal Alkan More articles by this author , and Semra KahramanSemra Kahraman More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1998AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The aim of the present study was to evaluate the effect of medical treatment and serum sex steroid levels on sperm retrieval rate in classic Klinefelter cases. METHODS From June 2002 to September 2013, a total of 89 classic Klinefelter patients whose data had been found were evaluated. Patients age and infertility time were recorded, and serum gonadotropin and sex steroid levels were measured. If serum testosterone level was less than 1.5 ng/ml, hCG treatment was performed for 4 months, and serum hormone levels were measured again. The patients were divided into two groups according to Micro TeSe results and taking medical treatment. Age, infertility time and serum sex steroid hormone level were compared in groups with Student-t test. The effect of medical treatment on sperm retrieval rate was compared by using Pearson Chi square test. Additionally, the effect of male age, infertility time and sex steroid levels on Micro TeSe was evaluated by using correlation test. RESULTS Patients’ age, infertility time and sex steroid levels are given in the table according Micro Tese results and treatment method. While sperm retrieval rate was 23.9% (11/46) in patients no-performed medical treatment, it was 65.9% (31/47) in medical treatment performed group (Pearson χ2=20.702, p=0.001). However, there was close and meaningful negative correlation between Micro TeSe results and patients agend infertility time (Age: r= -.341, p=0.001; Infertility time: r= -.260, p=0.001). CONCLUSIONS While sperm retrieval rate with micro TeSe was higher in Klinefelter cases after medical treatment and in higher serum testosterone levels, the age of the cases and aging process of the testicular tissue by the year was the most important factors affected sperm extraction in Klinefelter cases. Micro TeSe Treatment Positive (n=42) Negative (n=51) p Performed (n=47) Non-performed (n=46) p Age (years) 32.1±4.7 35.7±5.3 0.001* 32.4±4.9 33.6±5.2 0.300 Infertility time (Years) 6.7±4.7 9.7±5.3 0.001* 7.5±5.1 7.6±5.8 0.753 FSH (mIU/ml) 37.6±15.9 38.3±14.2 0.726 37.0±15.3 38.3±14.2 0.726 LH (mIU/ml) 19.6±7.8 19.9±8.0 0.842 18.9±6.5 22.2±8.1 0.133 Testosterone (ng/ml) 2.8±1.6 2.6±1.3 0.239 2.9±1.5 2.4±1.3 0.101 E2 (pg/ml) 31.7±11.9 40.4±16.2 0.312 34.7±13.4 36.9±19.7 0.862 © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e733 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Mehmet Murad Basar More articles by this author Nur Dokuzeylul-Gungor More articles by this author Yesim Kumtepe-Colakoglu More articles by this author Serkan Selimoglu More articles by this author Erdal Alkan More articles by this author Semra Kahraman More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...