PD23-04 URINARY PROTEINS IN THE DIAGNOSIS OF MIXED INTRINSIC SPHINCTER DEFICIENCY AND DETRUSOR OVERACTIVITY IN FEMALE PATIENTS WITH STRESS URINARY INCONTINENCE?

Abstract

You have accessJournal of UrologyCME1 Apr 2023PD23-04 URINARY PROTEINS IN THE DIAGNOSIS OF MIXED INTRINSIC SPHINCTER DEFICIENCY AND DETRUSOR OVERACTIVITY IN FEMALE PATIENTS WITH STRESS URINARY INCONTINENCE? Wei-Hsin Chen, Yuan-Hong Jiang, and Hann-Chorng Kuo Wei-Hsin ChenWei-Hsin Chen More articles by this author , Yuan-Hong JiangYuan-Hong Jiang More articles by this author , and Hann-Chorng KuoHann-Chorng Kuo More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003296.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To investigate urinary biomarkers in women with stress urinary incontinence (SUI). METHODS: We retrospectively enrolled 93 female patients with SUI. The patients were categorized into the following three groups based on video-urodynamic findings: intrinsic sphincter deficiency (ISD) and detrusor overactivity (DO), ISD and hypersensitive bladder (HSB), and ISD and stable bladder (controls) groups. RESULTS: The mean age of the cohort was 60.8±10.7 (36–83) years (Table 1). Thirty-one (33.3%), 28 (30.1%), and 34 (36.6%) patients were included in the ISD and DO, ISD and HSB, and control groups, respectively. The ISD and DO group had significantly increased 8-isoprostane (mean, 33.285 vs. 10.795 pg/mL) and 8-hydroxy-2-deoxyguanosine (8-OHdG; mean, 28.912 vs. 17.416 ng/mL) and decreased interleukin (IL)-2 (mean, 0.433 vs. 0.638 pg/mL), vascular endothelial growth factor (mean, 5.506 vs. 8.989 pg/mL), and neural growth factor (mean, 0.175 vs. 0.235 pg/mL) levels than the controls (Figure 1). The analytes from controls were moderately diagnostic of DO, except for 8-isoprostane [area under the curve (AUC) >0.7]. Voided volume was highly diagnostic of DO from either controls or non-DO patients (AUC 0.750 and 0.915 respectively). The proposed prediction model with voided volume, 8-OHdG, and 8-isoprostane (cutoff values of 384 ml, 35 ng/mL, and 37 pg/mL, respectively) had an accuracy of 81.72% (sensitivity, 67.74%; specificity, 88.71%; positive predictive value, 75.00%; and negative predictive value, 84.62%). CONCLUSIONS: Combined with voided volume, urinary oxidative stress biomarkers have the potential to be used to identify urodynamic DO in patients with SUI. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e671 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Wei-Hsin Chen More articles by this author Yuan-Hong Jiang More articles by this author Hann-Chorng Kuo More articles by this author Expand All Advertisement PDF downloadLoading ...