PD22-11 SUBCLINICAL INFLAMMATION AS A PREDICTOR FOR ERECTILE DYSFUNCTION AFTER BRACHYTHERAPY FOR LOCALIZED PROSTATE CANCER

Abstract

You have accessJournal of UrologyCME1 May 2022PD22-11 SUBCLINICAL INFLAMMATION AS A PREDICTOR FOR ERECTILE DYSFUNCTION AFTER BRACHYTHERAPY FOR LOCALIZED PROSTATE CANCER Laurianne Rita Garabed, Daniel Taussky, Guila Delouya, and Daniel Liberman Laurianne Rita GarabedLaurianne Rita Garabed More articles by this author , Daniel TausskyDaniel Taussky More articles by this author , Guila DelouyaGuila Delouya More articles by this author , and Daniel LibermanDaniel Liberman More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002564.11AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Neutrophil-to-lymphocyte ratio (NLR), a marker for subclinical inflammation, has been previously shown to be associated with erectile dysfunction (ED). Treatment of localized prostate cancer (PCa) is also associated with a greater risk of ED. In this study, we aimed to determine the potential predictive value of the NLR on ED after prostate brachytherapy (PB) for PCa. METHODS: Between July 2005 and January 2021, 842 patients were included in this retrospective study of a prospectively maintained database. ED was assessed using the Common Terminology Criteria for Adverse Events (CTCAE) physician-reported scale. Patient characteristics and erectile function at last follow-up were compared for patients with a baseline NLR<2 and ≥2. Univariate and multivariate analyses were performed to evaluate the predictive value of baseline NLR ≥2 on post-PB ED. RESULTS: Baseline NLR≥2 was found to be a statistically significant predictor of post-PB ED on both univariate (p=0.002) and multivariate analyses (p=0.008). Furthermore, the difference in ED prevalence between the NLR <2 and NLR ≥2 groups became more pronounced with longer follow-up after PB. The ED rate at 5 years post-PB was 43% for the NLR ≥2 group, compared to 29% for the NLR <2 group. CONCLUSIONS: In a large cohort of patients with PCa who underwent PB, it was found that NLR was a predictor of post-treatment ED, even after adjusting for available covariates, including age and known risk factors for endothelial dysfunction. Source of Funding: None © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e408 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Laurianne Rita Garabed More articles by this author Daniel Taussky More articles by this author Guila Delouya More articles by this author Daniel Liberman More articles by this author Expand All Advertisement PDF DownloadLoading ...