PD20-04 DOES AIR POLLUTION IMPACT ON SEMEN PARAMETERS: FINDINGS FROM A REAL-LIFE CROSS-SECTIONAL STUDY IN WHITE-EUROPEAN INFERTILE MEN

Abstract

You have accessJournal of UrologyCME1 May 2022PD20-04 DOES AIR POLLUTION IMPACT ON SEMEN PARAMETERS: FINDINGS FROM A REAL-LIFE CROSS-SECTIONAL STUDY IN WHITE-EUROPEAN INFERTILE MEN Federico Belladelli, Giuseppe Fallara, Edoardo Pozzi, Massimiliano Raffo, Christian Corsini, Luigi Candela, Antonio Costa, Daniele Cignoli, Nicolò Schifano, Alessia d'Arma, Paolo Capogrosso, Luca Boeri, Eugenio Ventimiglia, Rayan Matloob, Luca Pagliardini, Enrico Papaleo, Vincenzo Mirone, Francesco Montorsi, and Andrea Salonia Federico BelladelliFederico Belladelli More articles by this author , Giuseppe FallaraGiuseppe Fallara More articles by this author , Edoardo PozziEdoardo Pozzi More articles by this author , Massimiliano RaffoMassimiliano Raffo More articles by this author , Christian CorsiniChristian Corsini More articles by this author , Luigi CandelaLuigi Candela More articles by this author , Antonio CostaAntonio Costa More articles by this author , Daniele CignoliDaniele Cignoli More articles by this author , Nicolò SchifanoNicolò Schifano More articles by this author , Alessia d'ArmaAlessia d'Arma More articles by this author , Paolo CapogrossoPaolo Capogrosso More articles by this author , Luca BoeriLuca Boeri More articles by this author , Eugenio VentimigliaEugenio Ventimiglia More articles by this author , Rayan MatloobRayan Matloob More articles by this author , Luca PagliardiniLuca Pagliardini More articles by this author , Enrico PapaleoEnrico Papaleo More articles by this author , Vincenzo MironeVincenzo Mirone More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , and Andrea SaloniaAndrea Salonia More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002558.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Air pollutants levels have been monitored closely for environmental and research issues in industrialized countries. We aimed to investigate the association between air pollutants levels and semen parameters in a cohort of white-European men seeking medical attention for primary couple’s infertility in Italy. METHODS: Complete demographic and laboratory data from 1152 infertile men consecutively assessed between 01/2015 and 12/2019 were analysed. Semen analyses were based on the 2010 WHO reference criteria. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI). We analyzed the annual average level of the three main markers of air pollution (Pm10, Pm2.5, and NO2) between 2014-2018 (Legambiente, 2020, Annual dossier series on air quality in Italy, referring the European Environmental Agency) relative to patients’ addresses over the last 5 years. Descriptive statistics and linear regression analyses were used to test the association between air pollutants levels and semen parameters. RESULTS: Overall, median (IQR) age and BMI were 37 (33-41) years and 24.3 (22.7-26.5) kg/m2, respectively. A CCI score ≥1 was found in 98 (8.5%) men, and 318 (27.6%) participants were active smokers. Of 1152 men, 87 (7.6%) had normal sperm parameters. Of 1065 patients with abnormal semen analyses, 237 (22.3%), 324 (30.4%), and 287 (27.0%) patients presented 1, 2 or 3 abnormalities, respectively; 217 (20.38%) patients were azoospermic. At linear regression analysis, Pm10, Pm2.5, and NO2 were negatively associated with sperm morphology (Pm10: ß: -0.5288 µg/m3, p=0.001; Pm2.5: ß: -0.5240 µg/m3, p=0.019; NO2: ß: -0.4396 µg/m3, p <0.0001). Furthermore, the adjusted odds of sperm normal morphology <4% were 1.06 (95% CI 1.03-1.09; p=0.007) for Pm10, 1.07 (95% CI 1.03-1.11; p=0.007) for Pm 2.5, and 1.03 (95% CI 1.02-1.05; p=0.001) for NO2, respectively (Figure 1). CONCLUSIONS: Findings of this cross-sectional study showed that Pm10, Pm 2.5, and NO2 levels were negatively associated with sperm morphology; conversely, they were not consistently associated with an increased risk of other abnormal sperm parameters in infertile men. Further studies are needed to better characterize air pollution effects on sperm parameters. Source of Funding: None © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e356 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Federico Belladelli More articles by this author Giuseppe Fallara More articles by this author Edoardo Pozzi More articles by this author Massimiliano Raffo More articles by this author Christian Corsini More articles by this author Luigi Candela More articles by this author Antonio Costa More articles by this author Daniele Cignoli More articles by this author Nicolò Schifano More articles by this author Alessia d'Arma More articles by this author Paolo Capogrosso More articles by this author Luca Boeri More articles by this author Eugenio Ventimiglia More articles by this author Rayan Matloob More articles by this author Luca Pagliardini More articles by this author Enrico Papaleo More articles by this author Vincenzo Mirone More articles by this author Francesco Montorsi More articles by this author Andrea Salonia More articles by this author Expand All Advertisement PDF DownloadLoading ...