PD20-02 PENILE TRACTION THERAPY INCREASES STRETCHED PENILE LENGTH AND ENDOTHELIAL NITRIC OXIDE SYNTHASE EXPRESSION IN A BILATERAL CAVERNOUS NERVE CRUSH INJURY RAT MODEL

Abstract

You have accessJournal of UrologySexual Function/Dysfunction: Medical, Hormonal & Non-surgical Therapy I (PD20)1 Sep 2021PD20-02 PENILE TRACTION THERAPY INCREASES STRETCHED PENILE LENGTH AND ENDOTHELIAL NITRIC OXIDE SYNTHASE EXPRESSION IN A BILATERAL CAVERNOUS NERVE CRUSH INJURY RAT MODEL Brian Dick, Jacob Greenberg, Michael Polchert, Max Moore, Joseph Kim, Cameron Belding, Hogyoung Kim, Suresh Sikka, Asim Abdel-Mageed, Shams Halat, and Wayne Hellstrom Brian DickBrian Dick More articles by this author , Jacob GreenbergJacob Greenberg More articles by this author , Michael PolchertMichael Polchert More articles by this author , Max MooreMax Moore More articles by this author , Joseph KimJoseph Kim More articles by this author , Cameron BeldingCameron Belding More articles by this author , Hogyoung KimHogyoung Kim More articles by this author , Suresh SikkaSuresh Sikka More articles by this author , Asim Abdel-MageedAsim Abdel-Mageed More articles by this author , Shams HalatShams Halat More articles by this author , and Wayne HellstromWayne Hellstrom More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002009.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Prostate cancer is the most common type of solid-organ cancer in men. Early detection and treatment with radical prostatectomy has improved cancer-specific survival but is associated with penile shortening and erectile dysfunction. Penile traction therapy (PTT) has been demonstrated to increase stretched penile length (SPL) prior to penile prosthesis placement, and may improve erectile function in patients with Peyronie’s Disease. We aim to evaluate the efficacy of PTT in preserving penile length and erectile function after bilateral cavernous nerve crush injury (BCNI) in a rat model. METHODS: 24 Male Sprague-Dawley rats aged 11-13 weeks were randomly assigned to 3 groups (n=8, each): sham operation with no PTT (sham); BCNI without PTT (crush); and BCNI with PTT (traction). PTT was started on post-op day 3. A traction force of 1 Newton was applied to the penis for 30 minutes each day, for 28 days. Penis measurements were taken every 7 days. After 28 days of traction, the cavernous nerve was stimulated while recording mean arterial pressure (MAP) and intracavernosal pressure (ICP). Cavernosal tissue was excised and Western blot analysis for endothelial nitric oxide synthase (eNOS) was performed. Significance was determined using ANOVA and Tukey’s test. RESULTS: At 4 weeks after nerve injury, animals treated with traction therapy had significantly greater SPL compared to sham and crush groups (30.0mm vs 27.9mm and 27.1mm respectively). Animals who received a sham operation had significantly greater erectile function (ΔICP/MAP) compared to the crush group at all voltages (2.5V P <0.05, 5V P <0.05, and 7.5V P <0.05). There was no significant difference in erectile function between sham and traction or traction and crush at any voltage. The traction group had significantly greater eNOS expression in cavernosal tissue compared to the crush group. CONCLUSIONS: Findings from this animal study suggest that PTT has the potential to mitigate penile retraction after prostatectomy. While more studies are needed to determine the effect of PTT on preservation of erectile function, the increased eNOS expression observed in the traction group offers a potential protective mechanism of action. Source of Funding: SMSNA © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e367-e367 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Brian Dick More articles by this author Jacob Greenberg More articles by this author Michael Polchert More articles by this author Max Moore More articles by this author Joseph Kim More articles by this author Cameron Belding More articles by this author Hogyoung Kim More articles by this author Suresh Sikka More articles by this author Asim Abdel-Mageed More articles by this author Shams Halat More articles by this author Wayne Hellstrom More articles by this author Expand All Advertisement Loading ...