PD20-01 CLINICAL TRIAL REPORTING AND REPRESENTATION OF RACE AND ETHNICITY IN UROLOGY 2007-2020

Abstract

You have accessJournal of UrologyCME1 Apr 2023PD20-01 CLINICAL TRIAL REPORTING AND REPRESENTATION OF RACE AND ETHNICITY IN UROLOGY 2007-2020 Christopher J. Magnani, Brandon E. Turner, Jecca R. Steinberg, Xinyuan Zhang, Ryan Brewster, Jason Qian, Alexander P. Cole, Conor Driscoll, Alexander Bell, Brannon T. Weeks, Tina Hernandez-Boussard, James D. Brooks, Kymora Scotland, Quoc-Dien Trinh, and Elodi J. Dielubanza Christopher J. MagnaniChristopher J. Magnani More articles by this author , Brandon E. TurnerBrandon E. Turner More articles by this author , Jecca R. SteinbergJecca R. Steinberg More articles by this author , Xinyuan ZhangXinyuan Zhang More articles by this author , Ryan BrewsterRyan Brewster More articles by this author , Jason QianJason Qian More articles by this author , Alexander P. ColeAlexander P. Cole More articles by this author , Conor DriscollConor Driscoll More articles by this author , Alexander BellAlexander Bell More articles by this author , Brannon T. WeeksBrannon T. Weeks More articles by this author , Tina Hernandez-BoussardTina Hernandez-Boussard More articles by this author , James D. BrooksJames D. Brooks More articles by this author , Kymora ScotlandKymora Scotland More articles by this author , Quoc-Dien TrinhQuoc-Dien Trinh More articles by this author , and Elodi J. DielubanzaElodi J. Dielubanza More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003286.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To assess reporting and representation of race and ethnicity in United States (US) based clinical trials focused on urology. METHODS: We performed a cross-sectional study of US based trials (2007-2020) with results reported to the ClinicalTrials.gov registry. We examined whether race and ethnicity data were reported, evaluated changes over time with Mann-Kendall trend test, and compared race and ethnicity representation (proportion of enrolled participants reported as White, Black, Hispanic, Asian, or Native American) within trial funding sponsor (Industry, US Government, Academic) and urologic subspecialty (Oncology, Andrology, Endourology, Female, General Urology, Pediatrics, Renal Transplant). RESULTS: Of 9,015 urologic trials, 39.7% (3,583) were US-based of which 837 (23.4%) reported results to the registry. 417 (49.8%) reported any race and ethnicity data, involving 37,465 participants. Reporting increased over time (Figure 1, p<0.001). Reporting was significantly associated with sponsor (p<0.001, US Government outperforming Industry and Academic) and subspecialty (p=0.02, highest with Oncology and lowest with Endourology and General Urology) (Table). Racial and ethnic minorities (15.0%) were underrepresented relative to US Census data (27.6%), most notable with Hispanic patients (3.6% vs 15.4%, respectively). Trial diversity was significantly associated with subspecialty (p<0.001) but not sponsor (p=0.18). Oncology (13.3%) and Female (12.7%) had the least trial diversity while Pediatrics (30.6%) and Renal Transplant (41.0%) were the most diverse. CONCLUSIONS: Inadequate reporting of race and ethnicity data in clinical trials impedes understanding of barriers to trial diversity. Reported data demonstrates urologic clinical trials are not representative of the US population. This lack of representation perpetuates health disparities, with serious repercussions for underrepresented groups and for the field as a whole. Urology as a field should strive to improve diversity in clinical trial enrollment. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e583 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Christopher J. Magnani More articles by this author Brandon E. Turner More articles by this author Jecca R. Steinberg More articles by this author Xinyuan Zhang More articles by this author Ryan Brewster More articles by this author Jason Qian More articles by this author Alexander P. Cole More articles by this author Conor Driscoll More articles by this author Alexander Bell More articles by this author Brannon T. Weeks More articles by this author Tina Hernandez-Boussard More articles by this author James D. Brooks More articles by this author Kymora Scotland More articles by this author Quoc-Dien Trinh More articles by this author Elodi J. Dielubanza More articles by this author Expand All Advertisement PDF downloadLoading ...