PD19-05 A COMPARISON OF THE SURVIVAL OUTCOMES OF ROBOTIC-ASSISTED RADICAL PROSTATECTOMY AND RADIATION THERAPY FOR LOCALIZED/LOCALLY ADVANCED PROSTATE CANCER IN MEN OVER 75 YEARS OLD; A KOREAN MULTICENTER STUDY

Abstract

You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy II (PD19)1 Sep 2021PD19-05 A COMPARISON OF THE SURVIVAL OUTCOMES OF ROBOTIC-ASSISTED RADICAL PROSTATECTOMY AND RADIATION THERAPY FOR LOCALIZED/LOCALLY ADVANCED PROSTATE CANCER IN MEN OVER 75 YEARS OLD; A KOREAN MULTICENTER STUDY Young-Hwii Ko, Jae Young Joung, Seok-Soo Byun, U-Syn Ha, Sung-woo Park, Seong Soo Jeon, and Cheol Kwak Young-Hwii KoYoung-Hwii Ko More articles by this author , Jae Young JoungJae Young Joung More articles by this author , Seok-Soo ByunSeok-Soo Byun More articles by this author , U-Syn HaU-Syn Ha More articles by this author , Sung-woo ParkSung-woo Park More articles by this author , Seong Soo JeonSeong Soo Jeon More articles by this author , and Cheol KwakCheol Kwak More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002008.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To determine and compare overall survivals (OSs) and cancer-specific survivals (CSSs) after robotic-assisted radical prostatectomy (RARP) and radiation therapy (RT), the latter of which has long been recommended primarily for elderly patients (≥75 years) with non-metastatic prostate cancer (PCa), given the contemporary Korean life span of 79.7 years (2018). METHODS: Retrospective data for aged ≥ 75 years who underwent RARP or RT at seven tertiary hospitals were analyzed. To account for indication-related bias, inverse probability of treatment-weighting (IPTW) was applied before unadjusted and adjusted Cox proportional hazards regression modeling. RESULTS: Of the 1,110 study subjects, 883 underwent RARP and 227 RT. Though there were differences in the age distribution (≥80 yrs; 25.4% vs 32.8%, p=.034), concomitant diabetes (14.9% vs 22.9%, p=.007) and coronary heart disease (3.5% vs. 7.5%, p=.015), and particularly in PCa risk stratification (high risk; 18.2 vs. 59.7%, p<.001) between groups, all of these were balanced after IPTW. During a mean follow-up of 74.5 months, OSs (91.9% vs. 91.0%) and CSSs (97.8% vs. 98.0%) were similar. After IPTW, OS was negatively associated with diabetes (HR=2.27, p<.001) and risk stratification (low-risk; HR=.0314, p<.001), the last of which was solely associated with CSS (HR=.245, p=.0005). The implementation of local treatment between RARP and RT demonstrated no impact on survival both in whole subjects and in the high-risk subpopulation. CONCLUSIONS: Even the patient over 75 years old who could afford to undergo RARP for non-metastatic PCa had a similar survival in comparison with RT, regardless of risk stratification. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e363-e363 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Young-Hwii Ko More articles by this author Jae Young Joung More articles by this author Seok-Soo Byun More articles by this author U-Syn Ha More articles by this author Sung-woo Park More articles by this author Seong Soo Jeon More articles by this author Cheol Kwak More articles by this author Expand All Advertisement Loading ...