PD18-12 INVESTIGATION OF RACE AND ASSOCIATED SOCIOECONOMIC FACTORS IN SURVIVAL OUTCOMES FOR PATIENTS WITH RENAL CELL CARCINOMA

Abstract

You have accessJournal of UrologyCME1 May 2022PD18-12 INVESTIGATION OF RACE AND ASSOCIATED SOCIOECONOMIC FACTORS IN SURVIVAL OUTCOMES FOR PATIENTS WITH RENAL CELL CARCINOMA Ridwan Alam, Mary Rostom, Sunil Patel, Solomon Woldu, Yasser Ged, and Nirmish Singla Ridwan AlamRidwan Alam More articles by this author , Mary RostomMary Rostom More articles by this author , Sunil PatelSunil Patel More articles by this author , Solomon WolduSolomon Woldu More articles by this author , Yasser GedYasser Ged More articles by this author , and Nirmish SinglaNirmish Singla More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002556.12AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Investigating the racial underpinnings of disease is challenging due to several confounding factors, most notably socioeconomics. We investigate the effect of race, comparing blacks versus whites, on overall survival (OS) in patients with renal cell carcinoma (RCC) using a national registry, with attention to baseline socioeconomic differences. METHODS: We queried the National Cancer Database (NCDB) for patients diagnosed with RCC between 2004 and 2017 with complete baseline demographic data available. Comparative statistics were used for baseline comparisons. Multivariable Cox proportional hazards regression with adjustment for socioeconomic and disease factors was performed for OS. RESULTS: A total of 471,833 patients with RCC were included, of whom 57,919 (12.4%) were black. Compared to whites, black patients were younger (61 years vs. 64 years, P<0.001), more comorbid (P<0.001), less likely to have private insurance (36.7% vs. 44.5%, P<0.001), more likely to be in a lower income bracket (P<0.001), more likely to be diagnosed with non-clear cell RCC (54.0% vs. 24.8%, P<0.001), and more likely to present at a lower cancer stage (P<0.001). The proportion of blacks diagnosed with RCC has increased over time (P<0.001). On multivariable Cox regression, black race was associated with worse OS. This remained true for subanalyses in patients with clear cell RCC only and in those with small renal masses (cT1aN0M0) only. Other significant predictors of worse OS included lack of insurance, lower income, and non-clear cell histology [Table]. Among patients with metastatic disease at diagnosis, in which mortality is more likely to be cancer-specific, race and insurance status were no longer significant predictors of OS. Instead, the receipt of systemic therapy, which was higher in whites (64.3% vs. 59.4%, P<0.001), and RCC histology were among the strongest predictors of OS. CONCLUSIONS: While socioeconomic disparities are evident between blacks and whites with RCC and likely play a role in influencing OS, survival differences are still apparent even after accounting for these differences. This may be due, in part, to inherent biological differences in RCC between blacks and whites, which warrants further investigation. Source of Funding: None © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e348 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ridwan Alam More articles by this author Mary Rostom More articles by this author Sunil Patel More articles by this author Solomon Woldu More articles by this author Yasser Ged More articles by this author Nirmish Singla More articles by this author Expand All Advertisement PDF DownloadLoading ...