PD18-07 SERUM ANTI-MÜLLERIAN HORMONE IN RELATION TO SPERM RETRIEVAL RATE AND TESTICULAR HISTOPATHOLOGY IN NON-OBSTRUCTIVE AZOOSPERMIA

Abstract

You have accessJournal of UrologyCME1 Apr 2023PD18-07 SERUM ANTI-MÜLLERIAN HORMONE IN RELATION TO SPERM RETRIEVAL RATE AND TESTICULAR HISTOPATHOLOGY IN NON-OBSTRUCTIVE AZOOSPERMIA Tomoki Takeda, Shoichiro Iwatsuki, Satoshi Nozaki, Hidenori Nishio, Hiroki Kubota, Yasue Kubota, Hiroyuki Kamiya, Hidetoshi Akita, Kentaro Mizuno, Yutaro Hayashi, Yukihiro Umemoto, and Takahiro Yasui Tomoki TakedaTomoki Takeda More articles by this author , Shoichiro IwatsukiShoichiro Iwatsuki More articles by this author , Satoshi NozakiSatoshi Nozaki More articles by this author , Hidenori NishioHidenori Nishio More articles by this author , Hiroki KubotaHiroki Kubota More articles by this author , Yasue KubotaYasue Kubota More articles by this author , Hiroyuki KamiyaHiroyuki Kamiya More articles by this author , Hidetoshi AkitaHidetoshi Akita More articles by this author , Kentaro MizunoKentaro Mizuno More articles by this author , Yutaro HayashiYutaro Hayashi More articles by this author , Yukihiro UmemotoYukihiro Umemoto More articles by this author , and Takahiro YasuiTakahiro Yasui More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003273.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Anti-Müllerian hormone (AMH) is secreted by Sertoli cells. Although AMH has been suggested as a marker of spermatogenesis, the relationship between serum AMH and spermatogenesis in non-obstructive azoospermia (NOA) is unclear. Therefore, we investigated the relationship between serum AMH and sperm retrieval rate (SRR), testicular histopathology in NOA. METHODS: The study population consisted of 237 patients with NOA who underwent microdissection testicular sperm extraction and had their serum AMH levels measured between January 2015 and December 2021. NOA patients were classified into serum AMH levels <0.1 (detection limit, n=27), 0.1-4 (n=76), 4-8 (n=58) and ≥8 ng/ml (n=76), and SRRs were compared. In addition, NOA patients were classified into TH (tubular hyalinization, n=15), SCO (Sertoli cell only syndrome, n=132), MA (maturation arrest, n=57) and HS (hypospermatogenesis, n=33) groups. The percentage of patients with serum AMH levels <0.1 ng/ml and serum AMH levels were compared. RESULTS: SRR were 3.7%, 40.8%, 36.2% and 23.7% for serum AMH levels <0.1, 0.1-4, 4-8 and ≥8 ng/ml, respectively (Figure 1A), with a significant difference between serum AMH levels <0.1 ng/ml and the other groups (p<0.01). The percentages of patients with serum AMH levels below 0.1 ng/ml were 86.7%, 10.6%, 0% and 0% in TH, SCO, MA and HS groups, respectively (Figure 1B), with a significant difference between TH and the other groups (p<0.01). Serum AMH levels were 0.11±0.04, 6.91±6.59, 7.75±7.09 and 5.77±3.58 ng/ml for the four groups, respectively (Figure 1C), with a significant difference between TH and the other groups (p<0.01). CONCLUSIONS: When the serum AMH value ≥0.1 ng/ml, the higher the serum AMH value, the lower the SRR. On the other hand, serum AMH levels <0.1 ng/ml may suggest hyalinization of seminiferous tubules, loss of Sertoli cells and low possibility of sperm retrieval. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e505 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Tomoki Takeda More articles by this author Shoichiro Iwatsuki More articles by this author Satoshi Nozaki More articles by this author Hidenori Nishio More articles by this author Hiroki Kubota More articles by this author Yasue Kubota More articles by this author Hiroyuki Kamiya More articles by this author Hidetoshi Akita More articles by this author Kentaro Mizuno More articles by this author Yutaro Hayashi More articles by this author Yukihiro Umemoto More articles by this author Takahiro Yasui More articles by this author Expand All Advertisement PDF downloadLoading ...