PD15-10 OUTCOMES FOR PATIENTS UNDERGOING SPACEOAR PLACEMENT IN THE SALVAGE RADIATION THERAPY SETTING

Abstract

You have accessJournal of UrologyCME1 Apr 2023PD15-10 OUTCOMES FOR PATIENTS UNDERGOING SPACEOAR PLACEMENT IN THE SALVAGE RADIATION THERAPY SETTING Spencer H. Bell, Emma Helstrom, Eric M. Horwitz, Mark A. Hallman, Jessica Wong, Robert Uzzo, Alexander Kutikov, David Chen, Richard E. Greenberg, Marc C. Smaldone, Rosalia Viterbo, Nicole Uzzo, and Andres F. Correa Spencer H. BellSpencer H. Bell More articles by this author , Emma HelstromEmma Helstrom More articles by this author , Eric M. HorwitzEric M. Horwitz More articles by this author , Mark A. HallmanMark A. Hallman More articles by this author , Jessica WongJessica Wong More articles by this author , Robert UzzoRobert Uzzo More articles by this author , Alexander KutikovAlexander Kutikov More articles by this author , David ChenDavid Chen More articles by this author , Richard E. GreenbergRichard E. Greenberg More articles by this author , Marc C. SmaldoneMarc C. Smaldone More articles by this author , Rosalia ViterboRosalia Viterbo More articles by this author , Nicole UzzoNicole Uzzo More articles by this author , and Andres F. CorreaAndres F. Correa More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003262.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: SpaceOAR is a hydrogel spacer introduced to reduce rectal radiation dose, toxicity, and complications (bowel, urinary, and sexual) for prostate cancer patients undergoing radiation therapy (RTx). Yet, SpaceOAR placement outcomes in the salvage radiation population remain to be established. We aim to investigate the outcomes and complications associated with SpaceOAR placement in patients undergoing salvage RTx. METHODS: We reviewed our institutional Radiation Oncology database for patients undergoing salvage RTx from 01/2018–05/2022. We identified patients who had an attempted SpaceOAR placement and assessed success rate as well as complications associated with the placement and subsequent RTx. We tested associations using the statistical t-test, with p-values <0.05 considered statistically significant. RESULTS: We identified 36 patients who underwent salvage high dose-rate brachytherapy. 22 patients had an attempted SpaceOAR placement prior to salvage RTx, of which 20 (90.1%) were successful. All SpaceOAR placements were performed in the operating room. The two unsuccessful SpaceOAR placements were aborted due to 1) diffusion along the anterior rectal wall and 2) inadequate hydro-dissection due to encountering dense fibrotic tissue. The average interval between SpaceOAR placement and prior RTx was 112 months (±46 months). No patients developed an acute complication that prevented them from receiving their scheduled salvage radiation therapy. Of the patients that underwent attempted SpaceOAR placement and then completed salvage RTx, five reported uncomplicated hematuria (22.7%), one developed a recto-urethral fistula (4.5%), two experienced acute urinary retention (9.1%), and one reported pain (4.5%). CONCLUSIONS: Here we present the first series of patients in the salvage radiation setting undergoing SpaceOAR placement. In well selected patients, SpaceOAR hydrogel placement is safe in the setting of salvage radiation therapy. Hydrogel placement was successful in over 90% of the patients who had an attempted placement. No post-procedure complications occurred that delayed or prevented salvage treatment. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e422 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Spencer H. Bell More articles by this author Emma Helstrom More articles by this author Eric M. Horwitz More articles by this author Mark A. Hallman More articles by this author Jessica Wong More articles by this author Robert Uzzo More articles by this author Alexander Kutikov More articles by this author David Chen More articles by this author Richard E. Greenberg More articles by this author Marc C. Smaldone More articles by this author Rosalia Viterbo More articles by this author Nicole Uzzo More articles by this author Andres F. Correa More articles by this author Expand All Advertisement PDF downloadLoading ...