PD14-11 MATERNAL FAMILY HISTORY OF UROLITHIASIS IS ASSOCIATED WITH EARLIER ONSET OF URINARY STONE DISEASE: RESULTS FROM ReSKU

Abstract

You have accessJournal of UrologyStone Disease: Epidemiology & Evaluation I (PD14)1 Sep 2021PD14-11 MATERNAL FAMILY HISTORY OF UROLITHIASIS IS ASSOCIATED WITH EARLIER ONSET OF URINARY STONE DISEASE: RESULTS FROM ReSKU Rei Unno, Kazumi Taguchi, Manint Usawachintachit, Heiko Yang, Fadl Hamouche, Justin Ahn, David Bayne, Marshall Stoller, and Thomas Chi Rei UnnoRei Unno More articles by this author , Kazumi TaguchiKazumi Taguchi More articles by this author , Manint UsawachintachitManint Usawachintachit More articles by this author , Heiko YangHeiko Yang More articles by this author , Fadl HamoucheFadl Hamouche More articles by this author , Justin AhnJustin Ahn More articles by this author , David BayneDavid Bayne More articles by this author , Marshall StollerMarshall Stoller More articles by this author , and Thomas ChiThomas Chi More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001990.11AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Family history of urolithiasis is a known risk factor for kidney stones. The direct relationship between family history and the severity of clinical presentation for kidney stone formers is not yet well documented. In this study, we evaluated the impact of family history on the severity of disease and age of onset in patients with urolithiasis. METHODS: This was an analysis of prospectively collected data from Registry for Stones of the Kidney and Ureter (ReSKU) from a single institution between October 2015 and December 2020. Demographics, clinical, and family history information from urolithiasis patients were collected. The family history information was further characterized to highlight the type of relationship (first vs first- and second-degree relatives) as well as the parental sidedness of the relationship (paternal vs maternal). This detailed family history was then linked to patient clinical data, including number of previous stone episodes, bilaterality, age of stone onset, 24-hour urine evaluation, and recurrent stone events during follow-up. Our primary endpoint was the number of patients experiencing at least one recurrent stone event during the study period. RESULTS: A total of 1566 patients were analyzed for this study. 603 patients (38.5%) had a family history of urolithiasis. On univariate analysis, a positive family history was associated with a higher number of recurrent stone events during the follow-up period (38.2% vs 27.6% p=0.001), an earlier onset of kidney stones, a higher percentage of bilateral disease, a higher number of previous stone episodes as well as more significant hypercalciuria on 24 hours urine collections (Table1). On multivariate analysis, any family history was associated with an increased risk of recurrent stone events. The presence of both a first and a second degree relative was associated with the highest odds ratio for recurrent stone event (OR 2.23 p <0.001), while having a maternal side relative conferred a higher odds ratio for a younger onset of stones (OR 2.53 p <0.001). CONCLUSIONS: The presence of any family history of kidney stone disease imparts an increased severity of urinary stone disease on patients. Furthermore, the presence of a maternal side relative with kidney stones may be a predictor for an earlier onset of urolithiasis. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e220-e220 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Rei Unno More articles by this author Kazumi Taguchi More articles by this author Manint Usawachintachit More articles by this author Heiko Yang More articles by this author Fadl Hamouche More articles by this author Justin Ahn More articles by this author David Bayne More articles by this author Marshall Stoller More articles by this author Thomas Chi More articles by this author Expand All Advertisement Loading ...