PD13-06 UTILITY OF A MOLECULAR SIGNATURE FOR PREDICTING RECURRENCE AND PROGRESSION IN NON-MUSCLE-INVASIVE BLADDER CANCER PATIENTS: COMPARISON WITH THE EORTC, CUETO AND 2021 EAU RISK GROUPS

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You have accessJournal of UrologyCME1 Apr 2023PD13-06 UTILITY OF A MOLECULAR SIGNATURE FOR PREDICTING RECURRENCE AND PROGRESSION IN NON-MUSCLE-INVASIVE BLADDER CANCER PATIENTS: COMPARISON WITH THE EORTC, CUETO AND 2021 EAU RISK GROUPS Xuan-Mei Piao, Yun-Sok Ha, Jae Hoon Kang, Seon-Kyu Kim, Seong-Hwan Park, Kyungchan Min, Hansoo Park, Kyeong Kim, Ho Won Kang, Sun Jin Song, Won Tae Kim, and Seok Joong Yun Xuan-Mei PiaoXuan-Mei Piao More articles by this author , Yun-Sok HaYun-Sok Ha More articles by this author , Jae Hoon KangJae Hoon Kang More articles by this author , Seon-Kyu KimSeon-Kyu Kim More articles by this author , Seong-Hwan ParkSeong-Hwan Park More articles by this author , Kyungchan MinKyungchan Min More articles by this author , Hansoo ParkHansoo Park More articles by this author , Kyeong KimKyeong Kim More articles by this author , Ho Won KangHo Won Kang More articles by this author , Sun Jin SongSun Jin Song More articles by this author , Won Tae KimWon Tae Kim More articles by this author , and Seok Joong YunSeok Joong Yun More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003260.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The utility of the clinicopathological risk estimators such as European Organization for Research and Treatment of Cancer (EORTC), Spanish Urology Association for Oncological Treatment (CUETO) models and EAU risk groups for predicting prognosis of non-muscle-invasive bladder cancer (NMIBC) is controversial. The aim of this study was to compare the utility of a molecular signature-based subtype predictor (MSP888) with the EORTC, CUETO risk tables and 2021 EAU risk groups in NMIBC patients. METHODS: A total of 178 NMIBC patients from Chungbuk National University Hospital (CBNUH) were enrolled, and the predictive value of the MSP888, EORTC, CUETO and 2021 EAU risk scores was compared. Of the 178 patients, 49 were newly analyzed by the RNA-sequencing for transcriptomic profiling, and their MSP888 subtype was evaluated according to previously developed molecular classifiers. The ability of the EORTC score, MSP888, Lund and UROMOL molecular subtypes to predict progression of 460 NMIBC patients from the UROMOL project was assessed. RESULTS: Cox regression analyses showed that the MSP888 subtype was an independent predictor of NMIBC progression in the CBNUH cohort (p<0.05). Particularly in patients not treated with BCG, MSP888 significantly linked with risk of disease recurrence and progression (both p<0.05). However, the EORTC, CUETO and 2021 EAU risk scores showed disappointing results with respect to estimating the NMIBC prognosis in the CBNUH cohort. The MSP888, Lund and UROMOL subtypes demonstrated a similar capacity to predict progression of NMIBC patients in the UROMOL cohort (all p<0.05). CONCLUSIONS: The molecular clustering predictor MSP888 is favorable for stratifying NMIBC patients to facilitate optimal treatment. Source of Funding: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (grant numbers- 2020R1I1A3062508 and 2021R1I1A1A01050891); and NRF funded by the Ministry of Science and ICT (MIST) (grant number- 2020R1F1A1068488); and NRF funded by the Korean government (grant numbers- 2014M3C9A306855425, 2021M3H9A209695312, and 2022R1A2C200848011); and by a grant from the Korea Research Institute of Bioscience and Biotechnology (KRIBB) Research Initiative Program (grant number- KGM5192221); and by a grant of the MD-PhD/Medical Scientist Training Program through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e407 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Xuan-Mei Piao More articles by this author Yun-Sok Ha More articles by this author Jae Hoon Kang More articles by this author Seon-Kyu Kim More articles by this author Seong-Hwan Park More articles by this author Kyungchan Min More articles by this author Hansoo Park More articles by this author Kyeong Kim More articles by this author Ho Won Kang More articles by this author Sun Jin Song More articles by this author Won Tae Kim More articles by this author Seok Joong Yun More articles by this author Expand All Advertisement PDF downloadLoading ...