PD13-12 EFFECTS OF RACE AND ETHNICITY ON THE INCIDENCE OF DEPRESSION AFTER PROSTATE CANCER TREATMENT

Abstract

You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History I (PD13)1 Sep 2021PD13-12 EFFECTS OF RACE AND ETHNICITY ON THE INCIDENCE OF DEPRESSION AFTER PROSTATE CANCER TREATMENT Dylan Peterson, Arjun Parthipan, Tina Hernandez-Boussard, Catherine Curtin, and James Brooks Dylan PetersonDylan Peterson More articles by this author , Arjun ParthipanArjun Parthipan More articles by this author , Tina Hernandez-BoussardTina Hernandez-Boussard More articles by this author , Catherine CurtinCatherine Curtin More articles by this author , and James BrooksJames Brooks More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001989.12AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Depression following prostate cancer treatment occurs in up to 1 in 5 men. Prior research has primarily focused on the impact of treatment modality on depression incidence; however, the contribution of other important patient factors, including race and ethnicity, remains unclear. Improved understanding of who is at risk of poor quality of life after treatment is needed. The aim of this study is to investigate the role of these demographic features on depression following prostate cancer treatment. METHODS: This is a retrospective cohort study of prostate cancer patients treated from 2001-2016 at the Veterans Health Administration (VHA) and 2007-2018 at Stanford Health Care (SHC). Evidence of depression from clinical text and diagnoses, demographic and treatment data were obtained from the electronic health records at each institution. Patients depressed prior to the start of treatment were excluded from analysis. Relative risk (RR) of new onset depression was calculated using univariable models. RESULTS: The final cohorts included 443,803 VHA and 9,350 SHC patients. Overall, VHA patients had higher rates of depression following treatment (87748 cases, 20% incidence) than SHC patients (477 cases, 5% incidence) (p <0.0001). Within the VHA population, compared to White patients, Black patients were at increased risk for depression (RR 1.04; 95% CI [1.02-1.06]; p <0.0001) while Asian patients had decreased risk for depression (RR 0.78; 95% CI [0.71-0.87]; p <0.0001). Hispanic or Latino ethnicity was also associated with increased risk for depression (RR 1.22; 95% CI [1.18-1.25]; p <0.0001). Additionally, relative to active surveillance, all treatment modalities were associated with increased risk for depression (RR for any treatment 1.26; 95% CI [1.31-1.41]; p <0.0001 for all comparisons). CONCLUSIONS: Patient race and ethnicity were significantly associated with the development of depression following prostate cancer treatment. These results can help clinicians better understand which survivors may be at increased risk of depression after treatment. Future work will include determining the role of potentially confounding factors including socioeconomic and insurance status on depression incidence in this population. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e214-e214 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Dylan Peterson More articles by this author Arjun Parthipan More articles by this author Tina Hernandez-Boussard More articles by this author Catherine Curtin More articles by this author James Brooks More articles by this author Expand All Advertisement Loading ...