PD13-03 COMPETING MORTALITY RISKS IN ELDERLY MEN WITH PROSTATE CANCER IN THE UNITED STATES

Abstract

You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History I (PD13)1 Apr 2020PD13-03 COMPETING MORTALITY RISKS IN ELDERLY MEN WITH PROSTATE CANCER IN THE UNITED STATES Muhammad Alam*, Daniel Norez, Jatinder Kumar, Karthik Tanneru, Shiva Gautam, Shahriar Koochekpour, Behzad Jazayeri, Soroush Bazargani, Sabine Nguyen, Hariharan Palayapalayam Ganapathi, Mark Bandyk, Joseph Costa, Robert Marino, and KC Balaji Muhammad Alam*Muhammad Alam* More articles by this author , Daniel NorezDaniel Norez More articles by this author , Jatinder KumarJatinder Kumar More articles by this author , Karthik TanneruKarthik Tanneru More articles by this author , Shiva GautamShiva Gautam More articles by this author , Shahriar KoochekpourShahriar Koochekpour More articles by this author , Behzad JazayeriBehzad Jazayeri More articles by this author , Soroush BazarganiSoroush Bazargani More articles by this author , Sabine NguyenSabine Nguyen More articles by this author , Hariharan Palayapalayam GanapathiHariharan Palayapalayam Ganapathi More articles by this author , Mark BandykMark Bandyk More articles by this author , Joseph CostaJoseph Costa More articles by this author , Robert MarinoRobert Marino More articles by this author , and KC BalajiKC Balaji More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000847.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The natural history of prostate cancer (PC) in men of > 70 years of age is not well defined. Although the current recommendation for PC screening is limited to 70 years of age, thousands of American men > 70 years of age are diagnosed annually with PC because of increasing life expectancy and continuing common practice of PC screening in men >70 years of age. In order to facilitate the best management strategies, we carried out competing risks analysis of elderly men diagnosed with PC of either dying from prostate cancer or other causes. METHODS: Data from 42810 patients who were diagnosed with PC from 2004 to 2016 were obtained from the Surveillance, Epidemiology, and End Results (SEER) database and stratified according to age into groups: 70 - 74, 75 - 79, 80 – 84, 85 - 89 and ≥90 years. The cause and non-cause mortality rates were calculated using competing risk estimates. RESULTS: Out of the total population studied, 10.1 % were African Americans, 78.4 % were Caucasians and rest other races. The follow up was censored at 10, 8 and 6 years for men 71-84, 85-89 and > 90 years of age respectively. Only 5% of the total population died of PC, 85% were alive and 10% died of other causes. The risks of dying from PC was highest in men with Gleason score (GS) > 7 PC across all age groups. Interestingly, while fewer than 10% of men with GS ≤ 7 died from PC across all age groups and vast majority died of other causes, the PC mortality was about 40% in men with GS > 7, which accounted for about half the deaths in men between 71 and 79 year of age. CONCLUSIONS: The study for the first time demonstrates the competing risks of mortality in elderly men diagnosed with prostate. Because about 40% of men diagnosed with GS > 7 prostate cancer died of the disease, which accounts for half the deaths in men 71 – 79 years of age, active intervention in this age group may be justified to improve clinical outcomes. Source of Funding: None © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e266-e267 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Muhammad Alam* More articles by this author Daniel Norez More articles by this author Jatinder Kumar More articles by this author Karthik Tanneru More articles by this author Shiva Gautam More articles by this author Shahriar Koochekpour More articles by this author Behzad Jazayeri More articles by this author Soroush Bazargani More articles by this author Sabine Nguyen More articles by this author Hariharan Palayapalayam Ganapathi More articles by this author Mark Bandyk More articles by this author Joseph Costa More articles by this author Robert Marino More articles by this author KC Balaji More articles by this author Expand All Advertisement PDF downloadLoading ...