PD12-06 ONCOLOGIC OUTCOMES PERINEPHRIC VERSUS SINUS FAT INVASION IN PATHOLOGIC T3A RENAL CELL CARCINOMA

Abstract

You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy II1 Apr 2018PD12-06 ONCOLOGIC OUTCOMES PERINEPHRIC VERSUS SINUS FAT INVASION IN PATHOLOGIC T3A RENAL CELL CARCINOMA Jeman Ryu, Se Young Choi, Jaehoon Lee, Wonchul Lee, Han Kyu Chae, Wonseok Choi, Bumjin Lim, Jae Hyeon Han, Teak Jun Shin, Yoon Soo Kyung, Sungchan Park, Kyung Hyun Moon, Dalsan You, In Gab Jeong, Jun Hyuk Hong, Hanjong Ahn, and Choung-Soo Kim Jeman RyuJeman Ryu More articles by this author , Se Young ChoiSe Young Choi More articles by this author , Jaehoon LeeJaehoon Lee More articles by this author , Wonchul LeeWonchul Lee More articles by this author , Han Kyu ChaeHan Kyu Chae More articles by this author , Wonseok ChoiWonseok Choi More articles by this author , Bumjin LimBumjin Lim More articles by this author , Jae Hyeon HanJae Hyeon Han More articles by this author , Teak Jun ShinTeak Jun Shin More articles by this author , Yoon Soo KyungYoon Soo Kyung More articles by this author , Sungchan ParkSungchan Park More articles by this author , Kyung Hyun MoonKyung Hyun Moon More articles by this author , Dalsan YouDalsan You More articles by this author , In Gab JeongIn Gab Jeong More articles by this author , Jun Hyuk HongJun Hyuk Hong More articles by this author , Hanjong AhnHanjong Ahn More articles by this author , and Choung-Soo KimChoung-Soo Kim More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.642AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES We investigated the influence of perinephric fat invasion (PFI) and sinus fat invasion (SFI) on the oncologic outcomes after radical nephrectomy (RN) or partial nephrectomy (PN) for pathologic T3a renal cell carcinoma (RCC). METHODS Among 3192 patients who underwent RN or PN in our institution between 1998 and 2012, 390 patients were diagnosed with pathologic T3a RCC. Of this cohort, we excluded nodal or distant metastatic RCC, RCC with renal vein thrombosis, and RCC with perinephric and sinus fat invasion. Finally, 107 patients of PFI group and 58 patients of SFI group were included in this study. All patients underwent RN or PN. We compared the clinico-pathological characteristics and oncological outcomes between two groups, and factors predicting disease progression or survival were assessed. RESULTS There were no significant differences in age, gender, the American Society of Anesthesiologists (ASA) status classification, and preoperative estimated glomerular filtration rate (GFR) between two groups. The proportion of patients who underwent RN was significantly higher in the SFI group than PFI group (91.4% vs. 72.9%, p=0.005). Mean maximal tumor diameter in the patients of SFI group was also longer than PFI group (6.5cm vs. 5.9cm, p=0.013). Tumor laterality, Fuhrman grade, histology, and presence of lymphovascular invasion were not significantly different between two groups. In Kaplan-Meier analysis, there was no significantly difference in 3-year disease progression-1free survival (PFS; 83.0% vs. 75.3%, p=0.643), 3-year cancer-specific survival (CSS; 85.6% vs. 93.1%, p=0.373), and 3-year overall survival (OS; 82.7% vs. 89.9%, p=0.658) between PFI and SFI group. In multivariate analysis, longer maximal tumor diameter was an independent predicting factor of shorter PFS (HR: 1.17, p=0.006) and CSS (HR: 1.19, p=0.033). The predictors of shorter OS were older age (HR: 1.03, p=0.022) and longer maximal tumor diameter (HR: 1.13, p=0.021). CONCLUSIONS Sinus fat invasion compared to perinephric fat invasion was not associated with an increased risk of disease recurrence, cancer-specific death, or overall death. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e241 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Jeman Ryu More articles by this author Se Young Choi More articles by this author Jaehoon Lee More articles by this author Wonchul Lee More articles by this author Han Kyu Chae More articles by this author Wonseok Choi More articles by this author Bumjin Lim More articles by this author Jae Hyeon Han More articles by this author Teak Jun Shin More articles by this author Yoon Soo Kyung More articles by this author Sungchan Park More articles by this author Kyung Hyun Moon More articles by this author Dalsan You More articles by this author In Gab Jeong More articles by this author Jun Hyuk Hong More articles by this author Hanjong Ahn More articles by this author Choung-Soo Kim More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...