PD12-01 INTRA-OCULAR PRESSURE MONITORING DURING HORIZONTAL HEAD POSITIONING VERSUS STEEP HEAD DOWN, DURING ROBOTIC RADICAL PROSTATECTOMY - A RANDOMIZED CONTROLLED STUDY

Abstract

METHODS: We conducted a retrospective claim analysis linked to a patient survey administered to OAB patients, who were members of a California-based managed care organization. Study participants had 1 UI episodes/day and initiated Ach therapy between January 2008 and May 2012. Claims data were used to track health resource utilization through May 2013. A one-time patient questionnaire was administered to collect information on urinary symptoms, bother etc. RESULTS: A total of 655 patients were enrolled into the study (79.2% women; mean age 72.8 years, standard deviation (SD): 12.5). Patients were followed up for an average of 3.4 years based on their claims data. During the follow-up period, patients cycled through 1 to 6 unique Achs; 65% of the study population used only 1 Ach while 35% used 2 Achs (Table). Most patients (71.3%) discontinued Achs by the end of follow-up; discontinuation rates remained high with 2 Achs. The mean UI episodes/day observed ranged from 3.3-3.9 with use of 1 through 6 Achs. Over 80% of patients continued to be bothered by their bladder symptoms, whether or not they remained on Achs. CONCLUSIONS: In this population of OAB patients with UI, the mean UI episodes/day and the percent of patients still bothered by bladder symptoms remained relatively constant, regardless of the number of Achs attempted (1 to 6). In addition, discontinuation rates were high regardless of number of Achs attempted. This analysis suggests that continual Ach cycling is not an optimal treatment approach following failure of the first prescribed Ach.