PD11-02 EN BLOC RESECTION OF BLADDER TUMOURS (ERBT): MULTIVARIABLE ANALYSIS FOR PREDICTION OF RECURRENCE AT MID-TERM FOLLOW-UP

Abstract

You have accessJournal of UrologyBladder Cancer: Non-Invasive II1 Apr 2016PD11-02 EN BLOC RESECTION OF BLADDER TUMOURS (ERBT): MULTIVARIABLE ANALYSIS FOR PREDICTION OF RECURRENCE AT MID-TERM FOLLOW-UP Rodolfo Hurle, Massimo Lazzeri, NicolòMaria Buffi, Giovanni Lughezzani, Paolo Casale, Girolamo Fiorini, Roberto Peschechera, Luisa Pasini, Silvia Zandegiacomo, Piergiuseppe Colombo, Emanuela Morenghi, and Giorgio Guazzoni Rodolfo HurleRodolfo Hurle More articles by this author , Massimo LazzeriMassimo Lazzeri More articles by this author , NicolòMaria BuffiNicolòMaria Buffi More articles by this author , Giovanni LughezzaniGiovanni Lughezzani More articles by this author , Paolo CasalePaolo Casale More articles by this author , Girolamo FioriniGirolamo Fiorini More articles by this author , Roberto PeschecheraRoberto Peschechera More articles by this author , Luisa PasiniLuisa Pasini More articles by this author , Silvia ZandegiacomoSilvia Zandegiacomo More articles by this author , Piergiuseppe ColomboPiergiuseppe Colombo More articles by this author , Emanuela MorenghiEmanuela Morenghi More articles by this author , and Giorgio GuazzoniGiorgio Guazzoni More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.842AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES En bloc resection of bladder tumours (ERBT) is an innovative technique, which is shown to improve staging quality and reduce recurrence at early follow-ups. Outcome at mid- and long-term oncological follow-up is still debated. The aim of the study was to identify predictor factors of recurrence at mid-term oncological follow-up. METHODS An observational prospective longitudinal study was carried out at a University centre from June 2010 to February 2014. Patients with first diagnosis or with primary recurrence of clinically non-muscle invasive bladder cancer (NMIBC), having tumours of = 3 cm and = 4 lesions were enrolled. All the patients underwent electrical ERBT by a Collins loop. The primary study end-point was recurrence-free survival. Secondary outcomes were: feasibility, safety, the presence of detrusor muscle (DM) and the recurrence rate at the first follow-up (3 months) cystoscopy (RRFF-C). Statistical analysis was complemented with multivariable analysis for identification of risk factor for recurrence at mid-term-follow-up. RESULTS Of 87 enrolled patients, 2 showed a non-urothelial carcinoma and eleven showed muscle invasive bladder carcinoma at the definitive pathology. The study cohort consisted of 74 TCC NMIBC cases, mean age 71yrs ± 8, presenting with a mean tumour diameter of 2.05 ± 0.63 cm and a median number of resected tumours per patients of 1 (range 1-4). The two-year recurrence-free survival was 85.59%. All the ERBT samples showed the presence of DM and the RRFF-C was 5.4% (4/74). An extraperitoneal bladder perforation occurred in only one patient. At multivariable analysis, performed to assess the impact of possible prognostic factors on recurrence-free survival, only gender (male) and the presence of CIS were independent predictors of recurrence (table 1). When patients were stratified according to grade, gender and > 1 recurrence/year were independent predictors of recurrence only for patients with NMIBC-HG. CONCLUSIONS Our findings suggest that the presence of CIS and male gender might represent the most important risk factor for recurrence after two years of follow-up. Further studies with larger sample size and randomised vs. standard trans urethral resection remain mandatory. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e287-e288 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Rodolfo Hurle More articles by this author Massimo Lazzeri More articles by this author NicolòMaria Buffi More articles by this author Giovanni Lughezzani More articles by this author Paolo Casale More articles by this author Girolamo Fiorini More articles by this author Roberto Peschechera More articles by this author Luisa Pasini More articles by this author Silvia Zandegiacomo More articles by this author Piergiuseppe Colombo More articles by this author Emanuela Morenghi More articles by this author Giorgio Guazzoni More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...