PD09-08 IMPACT OF NEOADJUVANT CHEMOTHERAPY-INDUCED ACUTE KIDNEY INJURY ON ONCOLOGICAL OUTCOMES IN PATIENTS WHO UNDERWENT RADICAL CYSTECTOMY: A MULTICENTER RETROSPECTIVE STUDY

Abstract

You have accessJournal of UrologyCME1 Apr 2023PD09-08 IMPACT OF NEOADJUVANT CHEMOTHERAPY-INDUCED ACUTE KIDNEY INJURY ON ONCOLOGICAL OUTCOMES IN PATIENTS WHO UNDERWENT RADICAL CYSTECTOMY: A MULTICENTER RETROSPECTIVE STUDY Naoki Fujita, Masaki Momota, Hirotaka Horiguchi, Shingo Hatakeyama, Hiroyuki Ito, Takahiro Yoneyama, Yasuhiro Hashimoto, Shoji Nishimura, Kazuaki Yoshikawa, and Chikara Ohyama Naoki FujitaNaoki Fujita More articles by this author , Masaki MomotaMasaki Momota More articles by this author , Hirotaka HoriguchiHirotaka Horiguchi More articles by this author , Shingo HatakeyamaShingo Hatakeyama More articles by this author , Hiroyuki ItoHiroyuki Ito More articles by this author , Takahiro YoneyamaTakahiro Yoneyama More articles by this author , Yasuhiro HashimotoYasuhiro Hashimoto More articles by this author , Shoji NishimuraShoji Nishimura More articles by this author , Kazuaki YoshikawaKazuaki Yoshikawa More articles by this author , and Chikara OhyamaChikara Ohyama More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003240.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Neoadjuvant chemotherapy (NAC)-induced acute kidney injury (AKI) is a frequent complication in patients with muscle-invasive bladder cancer (MIBC). Although previous studies have reported that AKI during cancer treatment was associated with poor oncological outcomes in several cancers, the impact of NAC-induced AKI on oncological outcomes in patients with MIBC remains unclear. METHODS: This retrospective study included 398 patients who received 2-4 cycles of NAC followed by radical cystectomy (RC). AKI was defined according to the KDIGO criteria. Patients were divided into two groups: patients who developed AKI during NAC (AKI group) and patients who did not (non-AKI group). Multivariable Cox-proportional hazards regression analyses were performed to evaluate the impact of NAC-induced AKI on recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS). RESULTS: The median age and follow-up period were 69 years and 62 months, respectively. Of the 398 patients, 66 (17%) developed AKI during NAC (Table 1). The rates of <ypT2 and downstage in the AKI group were significantly lower than those in the non-AKI group (Figure 1A and B). RFS, CSS, and OS in the AKI group were significantly shorter than those in the non-AKI group (Figure 1C-E). After adjustment for confounding variables, AKI was significantly associated with shorter RFS (hazard ratio [HR] 1.619, p=0.043), CSS (HR 1.727, p=0.049), and OS (HR 1.848, p=0.008) (Table 2). CONCLUSIONS: NAC-induced AKI was associated with reduced effects of NAC and poor oncological outcomes in patients who underwent RC. Source of Funding: None. © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e243 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Naoki Fujita More articles by this author Masaki Momota More articles by this author Hirotaka Horiguchi More articles by this author Shingo Hatakeyama More articles by this author Hiroyuki Ito More articles by this author Takahiro Yoneyama More articles by this author Yasuhiro Hashimoto More articles by this author Shoji Nishimura More articles by this author Kazuaki Yoshikawa More articles by this author Chikara Ohyama More articles by this author Expand All Advertisement PDF downloadLoading ...