PD08-07 OUTCOMES OF RENAL TUMORS TREATED BY IMAGE-GUIDED PERCUTANEOUS CRYOABLATION: IMMEDIATE, 3- AND 5-YEAR OUTCOMES AT A REGIONAL CENTER

Abstract

You have accessJournal of UrologyKidney Cancer: Localized: Ablative Therapy (PD08)1 Apr 2020PD08-07 OUTCOMES OF RENAL TUMORS TREATED BY IMAGE-GUIDED PERCUTANEOUS CRYOABLATION: IMMEDIATE, 3- AND 5-YEAR OUTCOMES AT A REGIONAL CENTER Shankar Kumar*, Emma Lim, Matthew Seager, Sachin Modi, Indrajeet Mandal, Joana Neves, Simon Jones, Maxine Tran, Graham Munneke, Steve Bandula, and Miles Walkden Shankar Kumar*Shankar Kumar* More articles by this author , Emma LimEmma Lim More articles by this author , Matthew SeagerMatthew Seager More articles by this author , Sachin ModiSachin Modi More articles by this author , Indrajeet MandalIndrajeet Mandal More articles by this author , Joana NevesJoana Neves More articles by this author , Simon JonesSimon Jones More articles by this author , Maxine TranMaxine Tran More articles by this author , Graham MunnekeGraham Munneke More articles by this author , Steve BandulaSteve Bandula More articles by this author , and Miles WalkdenMiles Walkden More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000835.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The purpose of this study was to evaluate the immediate, and 3- and 5-year outcomes of patients with clinical stage T1 (cT1) biopsy-proven renal cell carcinoma (RCC) treated by image-guided percutaneous cryoablation at a regional interventional oncology center. METHODS: We interrogated a prospectively maintained local interventional radiology database and identified 180 patients in whom 185 separate cT1 RCC lesions were treated by percutaneous cryoablation. Technical success, procedural complications (graded using the Clavien-Dindo classification system), and the residual unablated tumor rate were collated. Local tumor progression-free survival was estimated using Kaplan-Meier methodology. RESULTS: Mean patient age was 68.4 years (range 34.1-88.9) and 52 (28.9%) were female. There were 168 (90.8%) and 17 (9.2%) cT1a and cT1b lesions, respectively, with a mean lesion size of 28.5 mm (range 11-58 mm). Technical success was achieved in 183/185 (98.9%). The major complication rate (Clavien-Dindo≥III) was 4/185 (2.1%). Residual unablated tumor on the first follow-up scan was identified in 3/183 (1.6%). Estimated local tumor progression-free survival at 3 and 5 years were 98.3% and 94.9%, respectively. No distant metastases or deaths attributable to RCC occurred. Mean eGFR pre procedure was 72.4 ml/min per 1.73m2 (SD±18.5) and this was not significantly different post-procedure (69.7, SD±18.8), at 1 year (70.7, SD±16.4) or 2 years (69.8, SD±18.9) (P>0.05). CONCLUSIONS: These data add to the accumulating evidence that image-guided cryoablation is an efficacious treatment for selected cT1 RCC with a low complication rate and robust 3- and 5-year outcomes. Source of Funding: None © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e170-e170 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Shankar Kumar* More articles by this author Emma Lim More articles by this author Matthew Seager More articles by this author Sachin Modi More articles by this author Indrajeet Mandal More articles by this author Joana Neves More articles by this author Simon Jones More articles by this author Maxine Tran More articles by this author Graham Munneke More articles by this author Steve Bandula More articles by this author Miles Walkden More articles by this author Expand All Advertisement PDF downloadLoading ...