PD06-05 FRACTIONAL CARBON DIOXIDE VAGINAL LASER FOR THE TREATMENT OF URINARY SYMPTOMS: 12 MONTHS RESULTS

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You have accessJournal of UrologyCME1 May 2022PD06-05 FRACTIONAL CARBON DIOXIDE VAGINAL LASER FOR THE TREATMENT OF URINARY SYMPTOMS: 12 MONTHS RESULTS Ly Hoang Roberts, Annah Vollstedt, Hailey Eisner, Lauren Tennyson, Evelyn Shea, Lisa Vargos, Danielle Tenney, Bernadette Zwaan, Larry Sirls, Priya Padmanabhan, and Kenneth Peters Ly Hoang RobertsLy Hoang Roberts More articles by this author , Annah VollstedtAnnah Vollstedt More articles by this author , Hailey EisnerHailey Eisner More articles by this author , Lauren TennysonLauren Tennyson More articles by this author , Evelyn SheaEvelyn Shea More articles by this author , Lisa VargosLisa Vargos More articles by this author , Danielle TenneyDanielle Tenney More articles by this author , Bernadette ZwaanBernadette Zwaan More articles by this author , Larry SirlsLarry Sirls More articles by this author , Priya PadmanabhanPriya Padmanabhan More articles by this author , and Kenneth PetersKenneth Peters More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002525.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Fractional carbon dioxide (fCO2) has been suggested to alleviate urinary symptoms such as frequency, urgency, urge urinary incontinence (UUI), and stress urinary incontinence (SUI) given its therapeutic effects on genitourinary symptoms of menopause (GSM). In a previous pilot study, we did not observe objective or subjective improvement in SUI at 6 months; however, there was a trend towards improvement for UUI. The goal of this study was to measure the effect of vaginal fCO2 laser therapy on SUI and OAB symptoms at 12 months. METHODS: After IRB approval, women > 18 years with urogenital symptoms were enrolled in an open-label prospective trial. A 3-month washout period was mandated for patients previously on vaginal estrogen therapy. Participants underwent 3 laser treatments, each 6 weeks apart from the previous. With baseline at time of treatment 1, cough stress test (CST) was performed at every visit while a voiding diary was completed at baseline, 6- and 12-months. Subjective data was obtained using the Incontinence-Quality of Life (I-QOL), Overactive Bladder Questionnaire short form (OABq-SF), Questionnaire for Urinary Incontinence Diagnosis (QUID), and Female Sexual Function Index (FSFI) at 6- and 12-months. ANOVA analysis with Dunnett’s multiple comparison was used to compare means at each time point. RESULTS: At time of analysis, 85 patients were enrolled. Of these, 36 patients had 12-month data and reported baseline SUI (n=25; 29%), frequency (n=28; 33%), urgency (n=29; 34%), or UUI (n=24; 28%). There was no statistically significant difference in number of SUI leaks (p=0.569) or rates of positive CST over time. Patients reported improvement on the I-QOL (mean ± SD diff: 12.23±10.90, p<0.0001) and QUID SUI sub-section (mean ± SD diff:-1.65±2.48, p=0.0065) at 12 months. There were no objective changes in frequency or UUI episodes, but urge intensity was significantly decreased at 12 months (mean ± SD diff: -0.28±0.51, p=0.0008). This correlated with a similar improvement in the OABq-SF and QUID UUI subsection (p=0.0003 and 0.002 at 12 m, respectively). CONCLUSIONS: In this study, we have demonstrated that vaginal fCO2 laser therapy significantly reduces urge intensity and improves patient reported symptom scores up to 12 months after onset of treatment. However, objective outcomes for SUI did not improve. Vaginal fCO2 laser may be a viable treatment option for women with GSM who suffer from urinary urgency, but it does not improve SUI. Source of Funding: Susan Cooper Fund/Women's Urology Center © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e94 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ly Hoang Roberts More articles by this author Annah Vollstedt More articles by this author Hailey Eisner More articles by this author Lauren Tennyson More articles by this author Evelyn Shea More articles by this author Lisa Vargos More articles by this author Danielle Tenney More articles by this author Bernadette Zwaan More articles by this author Larry Sirls More articles by this author Priya Padmanabhan More articles by this author Kenneth Peters More articles by this author Expand All Advertisement PDF DownloadLoading ...