PD05-05 THE INSIGNIFICANT EFFECT OF THE ANDROGEN DEPRIVATION THERAPY ON THE INCIDENCE OF DEMENTIA IN A RETROSPECTIVE POPULATION-BASED PROSTATE CANCER STUDY USING THE EXTENSION OF COX PROPORTIONAL HAZARD MODEL WITH TIME-DEPENDENT SURVIVAL

Abstract

You have accessJournal of UrologyProstate Cancer: Advanced (including Drug Therapy) I (PD05)1 Sep 2021PD05-05 THE INSIGNIFICANT EFFECT OF THE ANDROGEN DEPRIVATION THERAPY ON THE INCIDENCE OF DEMENTIA IN A RETROSPECTIVE POPULATION-BASED PROSTATE CANCER STUDY USING THE EXTENSION OF COX PROPORTIONAL HAZARD MODEL WITH TIME-DEPENDENT SURVIVAL Sung Han Kim, Young Ae Kim, Su-Hyun Kim, Jae Young Joung, and Min Soo Yang Sung Han KimSung Han Kim More articles by this author , Young Ae KimYoung Ae Kim More articles by this author , Su-Hyun KimSu-Hyun Kim More articles by this author , Jae Young JoungJae Young Joung More articles by this author , and Min Soo YangMin Soo Yang More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001969.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: This study aimed to evaluate the effect of androgen deprivation therapy (ADT) on the incidence of dementia after considering time-dependent survival in patients with prostate cancer (PC) using population-based data from the Korean National Insurance Database. METHODS: Between 2003 and 2013, a total of 31,571 patients with PC aged >50 years were grouped into ADT (N=16827, 53.3%) and non-ADT (N=14744, 46.7%) groups after excluding patients with cerebrovascular disease and dementia before or within 3-month-ADT and with surgical castration. The ADT and non-ADT groups were then statistically compared to define the significant relationship between the ADT duration and the prevalence of dementia and significant risk factors for overall survival (OS) until the end of 2014 using extension Cox proportional hazard model with p-values <0.05 regarded as statistically significant. RESULTS: Between ADT and non-ADT groups, several significant baseline differences were observed except for the year of dementia diagnosis, underlying disease, and antiplatelet therapy (p>0.05). A total of 2945 (9.3%) patients developed dementia during the study period and dementia group had several different factors from those with non-dementia group (N=28626, 90.7%), except for pathology and the rate of only antiandrogen therapy. The multivariate analysis of dementia incidence showed insignificance of none of ADT type ADT duration among overall PC patients (p>0.05). As for the risk factor for OS among PC patients with dementia, the multivariate showed that ADT type and ADT duration were significant factors (p<0.05). CONCLUSIONS: The study showed that insignificant correlation was observed between the ADT and the prevalence of dementia after extension Cox hazard model. However, the ADT type and duration significantly influenced on the OS among PC patients with dementia. Source of Funding: This work was supported by a grant from the National Cancer Center (No.1610310,1810021, and 1910171), Republic of Korea © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e57-e57 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Sung Han Kim More articles by this author Young Ae Kim More articles by this author Su-Hyun Kim More articles by this author Jae Young Joung More articles by this author Min Soo Yang More articles by this author Expand All Advertisement Loading ...