PD05-08 LIVE BIRTH RATES IN MEN WITH NON-OBSTRUCTIVE AZOOSPERMIA (NOA) UNDERGOING MICRODISSECTION TESTICULAR SPERM EXTRACTION (MTESE)

Abstract

You have accessJournal of UrologyInfertility: Therapy I1 Apr 2016PD05-08 LIVE BIRTH RATES IN MEN WITH NON-OBSTRUCTIVE AZOOSPERMIA (NOA) UNDERGOING MICRODISSECTION TESTICULAR SPERM EXTRACTION (MTESE) Chris Poullis, Saad Abumelha, Fahad Al Mashat, Nagla Rushwan, Tet Yap, Meen Yau Thum, Hossam Abdalla, and Suks Minhas Chris PoullisChris Poullis More articles by this author , Saad AbumelhaSaad Abumelha More articles by this author , Fahad Al MashatFahad Al Mashat More articles by this author , Nagla RushwanNagla Rushwan More articles by this author , Tet YapTet Yap More articles by this author , Meen Yau ThumMeen Yau Thum More articles by this author , Hossam AbdallaHossam Abdalla More articles by this author , and Suks MinhasSuks Minhas More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2615AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Sperm acquisition is often used as a primary end point in reporting outcomes from mTESE with live birth rates under reported in men with NOA. The aim of this study was to report live birth rates following mTESE and analyse factors affecting outcome. METHODS A retrospective review of patients undergoing a primary mTESE for NOA by a single surgeon was conducted from 2004 to 2015, reporting on outcomes from the first cycle of ICSI. The primary outcome measures were pregnancy and live birth rates. Multivariate analysis was used to analyse factors affecting live birth rates following ICSI including female/male age, Johnsen score, final histopathological diagnosis and the use of fresh versus frozen sperm. RESULTS A total of 230 patients were included. The mean age of male and female patients was 42.8 (range 27-74) and 33.4 (range 19-43) respectively. Sperm was retrieved in 105 of 230 (45.7%) of men. 83 patients had ICSI cycles. The mean number of eggs retrieved was 8.7 (range 1-26), with a mean of 4.5 eggs (range 0-12) fertilised. The mean number of embryos implanted was 1.8 and pregnancy rate was 43.8%, with a primary live birth rate of 17.3%. 28 (33.7%) of patients still had frozen sperm after the primary cycle and a further 43 ICSI cycles were performed with a cumulative live birth rate of 23.3%. There was no significant difference in pregnancy (p = 0.37) or live birth (p = 0.82) rates between fresh and frozen sperm. Pregnancy rates and number of successful embryo implants were associated with successful live births in the multivariate analysis. Age of male or female partners, Johnsen score or histology did not predict success. In 4 (4.8%) patients utilising cryopreserved samples, sperm was non viable on the day of egg retrieval. CONCLUSIONS Sperm can be retrieved in 46% of all men with NOA, although only 17.3% are able to achieve paternity, which is independent of the histological diagnosis. There is no difference in outcomes between fresh and frozen sperm, although patients should be counseled that in a small number, sperm will not survive cryopreservation. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e171-e172 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Chris Poullis More articles by this author Saad Abumelha More articles by this author Fahad Al Mashat More articles by this author Nagla Rushwan More articles by this author Tet Yap More articles by this author Meen Yau Thum More articles by this author Hossam Abdalla More articles by this author Suks Minhas More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...